| Long name: |
ALEXA FLUOR 488 Conjugated, NOTUM Polyclonal Antibody |
| Also known as: |
Anti-NOTUM PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
NOTUM |
| Specificity: |
This is a highly specific antibody against NOTUM |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NOTUM |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
BRCA1 is directly involved in DNA repair, Encoding more than 1, Like p53, Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome, The gene that encodes Notum consists of approximately 9, Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death, Two key tumor suppressor genes are associated with chromosome 17, chromosome 17 comprises over 2, colon, namely, p53 and BRCA1, prostate gland and fallopian tubes, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of ovary, 200 genes, 3, 334 bases and maps to human chromosome 17q25, 5% of the human genome, Notum is a 496 amino acid secreted protein that belongs to the pectinacetylesterase family and may deacetylate GlcNAc residues on cell surface glycans |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the NOTUM Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
NOTUM |
| Short name: |
NOTUM Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, NOTUM (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
27106 |
| Gene: |
NOTUM |
More about : NOTUM |
| Long gene name: |
NOTUM, palmitoleoyl-protein carboxylesterase |
| Synonyms gene name: |
notum pectinacetylesterase homolog (Drosophila) |
| Synonyms name: |
[Wnt protein] O-palmitoleoyl-L-serine hydrolase |
| Locus: |
17q25, 3 |
| Discovery year: |
2005-11-22 |
| GenBank acession: |
BC060882 |
| Entrez gene record: |
147111 |
| Pubmed identfication: |
25731175 |
| RefSeq identity: |
NM_178493 |
| Havana BLAST/BLAT: |
OTTHUMG00000154416 |