| Long name: |
ALEXA FLUOR 555 Conjugated, MEIS2 Polyclonal Antibody |
| Also known as: |
Anti-MEIS2 PAb ALEXA FLUOR 555 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
555, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
MEIS2 |
| Specificity: |
This is a highly specific antibody against MEIS2 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MEIS2 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Both Meis1 and Meis2 (also known as Meis-related gene 1 or Mrg1) are members of the TALE (â, Hox proteins are involved in regulating tissue patterning during development, In addition to binding with Hox proteins, In the pancreas, Like Hox and Pbx proteins, Meis1 also forms heterodimers with the ubiquitously expressed Pbx proteins, Meis1 is implicated in oncogenesis, Meis2 and Meis3 (also designated Mrg1 and Mrg2, Meis2 preferentially associates with Pbx1, Pbx and Meis families of transcription factors form heteromeric complexes and bind DNA through specific homeobox domains, Pbx2 and Pbx3, Pdx1, The Hox proteins, Two Meis-related proteins, and are also expressed in lineage- and stage-specific patterns during adult hematopoietic differentiation and in leukemias, and these complexes contain distinct DNA-binding specificities, and together they associate with the pancreas-specific homeodomain factor, as it is overexpressed as a result of adjacent retroviral insertion in BHX-2 myeloid leukemias, have a low intrinsic binding affinity for DNA and are instead associated into cooperative DNA binding complexes with Pbx or the Pbx- related Meis proteins, including Pbx1, possess largely similar sequence identity with Meis1 and are expressed in normal tissues and myeloid leukemias, respectively), to repress Pdx1-induced transcriptional activation, which include paralog groups 1-10, which result in an enhanced Hox-DNA binding affinity and an increased selectivity for the binding site, &euro, &euro, &oelig, Hox, three amino acid loop extensionâ, ) family of homeodomain-containing proteins |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
553nm/568nm |
| Synonyms: |
MRG1 HsT18361 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 555, Alexa Fluor |
| Gene target: |
MEIS2 |
| Short name: |
MEIS2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 555 |
| Alternative name: |
ALEXA FLUOR 555, MEIS2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
7001 |
| Gene: |
MEIS2 |
More about : MEIS2 |
| Long gene name: |
Meis homeobox 2 |
| Synonyms gene name: |
Meis (mouse) homolog 2 Meis1, myeloid ecotropic viral integration site 1 homolog 2 (mouse) |
| Locus: |
15q14 |
| Discovery year: |
1998-02-09 |
| GenBank acession: |
AF017418 |
| Entrez gene record: |
4212 |
| Pubmed identfication: |
9383298 |
| RefSeq identity: |
NM_170677 |
| Classification: |
TALE class homeoboxes and pseudogenes |
| Havana BLAST/BLAT: |
OTTHUMG00000129781 |