| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
MEIS2 |
| Specificity: |
This antibody reacts specifically with MEIS2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human MEIS2 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Both Meis1 and Meis2 (also known as Meis-related gene 1 or Mrg1) are members of the TALE (â, Hox proteins are involved in regulating tissue patterning during development, In addition to binding with Hox proteins, In the pancreas, Like Hox and Pbx proteins, Meis1 also forms heterodimers with the ubiquitously expressed Pbx proteins, Meis1 is implicated in oncogenesis, Meis2 and Meis3 (also designated Mrg1 and Mrg2, Meis2 preferentially associates with Pbx1, Pbx and Meis families of transcription factors form heteromeric complexes and bind DNA through specific homeobox domains, Pbx2 and Pbx3, Pdx1, The Hox proteins, Two Meis-related proteins, and are also expressed in lineage- and stage-specific patterns during adult hematopoietic differentiation and in leukemias, and these complexes contain distinct DNA-binding specificities, and together they associate with the pancreas-specific homeodomain factor, as it is overexpressed as a result of adjacent retroviral insertion in BHX-2 myeloid leukemias, have a low intrinsic binding affinity for DNA and are instead associated into cooperative DNA binding complexes with Pbx or the Pbx- related Meis proteins, including Pbx1, possess largely similar sequence identity with Meis1 and are expressed in normal tissues and myeloid leukemias, respectively), to repress Pdx1-induced transcriptional activation, which include paralog groups 1-10, which result in an enhanced Hox-DNA binding affinity and an increased selectivity for the binding site, &euro, &euro, &oelig, Hox, three amino acid loop extensionâ, ) family of homeodomain-containing proteins |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
MRG1 HsT18361 |
| Also known as: |
MEIS2 Polyclonal Antibody |
| Other name: |
Anti-MEIS2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
MEIS2 |
| Short name: |
Anti-MEIS2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-MEIS2 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
7001 |
| Gene: |
MEIS2 |
More about : MEIS2 |
| Long gene name: |
Meis homeobox 2 |
| Synonyms gene name: |
Meis (mouse) homolog 2 Meis1, myeloid ecotropic viral integration site 1 homolog 2 (mouse) |
| Locus: |
15q14 |
| Discovery year: |
1998-02-09 |
| GenBank acession: |
AF017418 |
| Entrez gene record: |
4212 |
| Pubmed identfication: |
9383298 |
| RefSeq identity: |
NM_170677 |
| Classification: |
TALE class homeoboxes and pseudogenes |
| Havana BLAST/BLAT: |
OTTHUMG00000129781 |