| Long name: |
CCM2/Malcavernin Primary Polyclonal Antibody |
| Also known as: |
CCM2/Malcavernin PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
CCM2/Malcavernin |
| Specificity: |
This is a highly specific antibody against CCM2/Malcavernin |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Malcavernin |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
CCM is caused by mutations in one of three genes: CCM1, CCM1 encodes the protein KRIT1, CCM2 encodes the protein Malcavernin and CCM3 shares its name with the protein it encodes, CCM2 or CCM3, Due to its lack of a nuclear export signal or nuclear localization signal, In addition, Isoform 1 represents the full length protein while isoform 2 contains an alternative four amino acid sequence rather than the first 10 residues of isoform 1, Like KRIT1, Malcavernin, Malcavernin is expresed in a variety of human organs including the arterial vascular endothelium, Malcavernin is expressed in various epithelial cells that are required for the formation of the blood-organ barrier, Malcavernin is localized to the cytoplasm but is known to shuttle to and from the nucleus, Two isoforms exist for Malcavernin, also designated cerebral cavernous malformations 2 protein, astrocytes and their foot processes, cerebral hemorrhages, headaches and focal neurologic deficits, is a scffolding protein for MEK kinase-3, it is believed that Malcavernin accomplishes this shuttling via an attachment to KRIT1, pyramidal neurons, seizures, which contains a nuclear localization signal, Cerebral cavernous malformation (CCM) is an autosomal dominant or sporadic neurovascular disease marked by vascular anomalies located mostly in the central nervous system that can cause stroke |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CCM2_HUMAN, Ccm2, Cerebral cavernous malformation 2, Cerebral cavernous malformations 2 protein, MGC4067, MGC4607, MGC74868, Malcavernin, PP10187, C7orf22 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
CCM2/Malcavernin |
| Short name: |
CCM2/Malcavernin Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
cerebral cavernous malformation 2/Malcavernin (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CCM2 and IDBG-15466 and ENSG00000136280 and 83605, CCM2 and IDBG-634072 and ENSBTAG00000008090 and 506450, Ccm2 and IDBG-148293 and ENSMUSG00000000378 and 216527, Cytoplasm, protein binding, this GO :0001568 and blood vessel development and biological process this GO :0001570 and vasculogenesis and biological process this GO :0001701 and in utero embryonic development and biological process this GO :0001885 and endothelial cell development and biological process this GO :0001944 and vasculature development and biological process this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0007229 and integrin-mediated signaling pathway and biological process this GO :0007507 and heart development and biological process this GO :0035264 and multicellular organism growth and biological process this GO :0043234 and protein complex and cellular component this GO :0045216 and cell-cell junction organization and biological process this GO :0048839 and inner ear development and biological process this GO :0048845 and venous blood vessel morphogenesis and biological process this GO :0051403 and stress-activated MAPK cascade and biological process this GO :0060039 and pericardium development and biological process this GO :0060837 and blood vessel endothelial cell differentiation and biological process this GO :0061154 and endothelial tube morphogenesis and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding, cerebral cavernous malformation 2 |
| Identity: |
21708 |
| Gene: |
CCM2 |
More about : CCM2 |
| Long gene name: |
CCM2 scaffolding protein |
| Synonyms gene: |
C7orf22 |
| Synonyms gene name: |
chromosome 7 open reading frame 22 cerebral cavernous malformation 2 |
| Synonyms: |
MGC4607 OSM |
| Synonyms name: |
malcavernin osmosensing scaffold for MEKK3 |
| Locus: |
7p13 |
| Discovery year: |
2003-07-14 |
| GenBank acession: |
BC004903 |
| Entrez gene record: |
83605 |
| Pubmed identfication: |
9811928 |
| RefSeq identity: |
NM_031443 |
| Havana BLAST/BLAT: |
OTTHUMG00000129246 |
| Locus Specific Databases: |
LRG_664 |