| Long name: |
Cy3 Conjugated, SPR/Sepiapterin reductase Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
cy3 conjugation kit |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
SPR/Sepiapterin reductase |
| Specificity: |
This is a highly specific antibody against SPR/Sepiapterin reductase |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human Sepiapterin reductase |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
BH4 is an essential cofactor for the hydroxylation of the aromatic amino acids (tryptophan, In addition, In addition, Mutations in the gene encoding SPR can cause sepiapterin reductase deficiency, SPR functions as an NADH-dependent aldo-keto reductase and specifically catalyzes the reduction of pteridine derivatives, SPR mRNA expression is increased in the brain of Parkinsonâ, SPR plays an important role in tetrahydrobiopterin (BH4) biosynthesis, Sepiapterin reductase deficiency interferes with BH4 synthesis, a monoamine neurotransmitter deficiency without hyperphenylalaninemia, also known as sepiapterin reductase, catalyzing the final reduction step of the synthesis pathway, is a homodimeric cytoplasmic protein that belongs to the sepiapterin reductase family, resulting in DOPA-responsive dystonia and a variety of other human diseases, suggesting that SPR may play a role in PD, tyrosine and phenylalanine) and is required for proper dopamine synthesis, &euro, &trade, SPR, s Disease (PD) patients |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
512, 550nm/570, 615nm |
| Synonyms: |
SDR38C1 |
| Properties: |
1 of the SPR/Sepiapterin reductase Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC, Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser, This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
SPR/Sepiapterin reductase Conjugated |
| Short name: |
Conjugated, SPR/Sepiapterin reductase Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Cy3 |
| Alternative name: |
cyanine 3 coupled, SPR/Sepiapterin reductase (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11257 |
| Gene: |
SPR |
More about : SPR |
| Long gene name: |
sepiapterin reductase (7, 8-dihydrobiopterin:NADP+ oxidoreductase) |
| Synonyms name: |
member 1 , short chain dehydrogenase/reductase family 38C |
| Locus: |
2p13, 2 |
| Discovery year: |
1991-12-05 |
| Entrez gene record: |
6697 |
| Pubmed identfication: |
1883349 19027726 |
| Classification: |
Short chain dehydrogenase/reductase superfamily |
| Havana BLAST/BLAT: |
OTTHUMG00000129777 |
| Locus Specific Databases: |
BIOMBD |