| Long name: |
Biotin Conjugated, LMX1b/NPS1 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
LMX1b/NPS1 |
| Specificity: |
This is a highly specific antibody against LMX1b/NPS1 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human LMX1b/NPS1 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
In addition, LMX1B along with LIM1 control the initial trajectory of motor axons in the developing mammalian limb, LMX1B belongs to the LIM-homeodomain family, LMX1B directly regulates the coordinated expression of alpha 3(IV) and alpha 4(IV) collagen required for normal glomerular basement membrane (GBM) morphogenesis, LMX1B is also necessary for normal development of the eye and in regulating dopaminergic neurogenesis and may be involved in developmental glaucoma and the aetiology of idiopathic Parkinsonâ, NPS is caused by putative loss-of-function mutations in the transcription factor LMX1B, Specifically, Twenty-two novel mutations may occur in the gene encoding LMX1B and the type and distribution of the mutations support the hypothesis that NPS is the result of haploinsufficiency for LMX1B, and the dysregulation of LMX1B in GBM contributes to the renal pathology and nephrosis in NPS, frequently, members of which are known to be important for pattern formation during development, renal disease, skeletal anomalies and, &euro, &trade, Nail-patella syndrome (NPS) is an autosomal dominant disorder characterized by dyplasia of finger nails, s disease |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
LMX1b/NPS1 Conjugated |
| Short name: |
Conjugated, LMX1b/NPS1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, LMX1b/NPS1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6654 |
| Gene: |
LMX1B |
More about : LMX1B |
| Long gene name: |
LIM homeobox transcription factor 1 beta |
| Synonyms gene: |
NPS1 |
| Synonyms gene name: |
LIM homeobox transcription factor 1, beta |
| Locus: |
9q33, 3 |
| Discovery year: |
1998-02-11 |
| GenBank acession: |
U77457 |
| Entrez gene record: |
4010 |
| Pubmed identfication: |
9441763 9590287 |
| Classification: |
LIM class homeoboxes |
| Havana BLAST/BLAT: |
OTTHUMG00000020692 |
| Locus Specific Databases: |
LRG_1014 |