| Long name: |
ALEXA FLUOR 488 Conjugated, LMX1b/NPS1 Polyclonal Antibody |
| Also known as: |
Anti-LMX1b/NPS1 PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
LMX1b/NPS1 |
| Specificity: |
This is a highly specific antibody against LMX1b/NPS1 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human LMX1b/NPS1 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
In addition, LMX1B along with LIM1 control the initial trajectory of motor axons in the developing mammalian limb, LMX1B belongs to the LIM-homeodomain family, LMX1B directly regulates the coordinated expression of alpha 3(IV) and alpha 4(IV) collagen required for normal glomerular basement membrane (GBM) morphogenesis, LMX1B is also necessary for normal development of the eye and in regulating dopaminergic neurogenesis and may be involved in developmental glaucoma and the aetiology of idiopathic Parkinsonâ, NPS is caused by putative loss-of-function mutations in the transcription factor LMX1B, Specifically, Twenty-two novel mutations may occur in the gene encoding LMX1B and the type and distribution of the mutations support the hypothesis that NPS is the result of haploinsufficiency for LMX1B, and the dysregulation of LMX1B in GBM contributes to the renal pathology and nephrosis in NPS, frequently, members of which are known to be important for pattern formation during development, renal disease, skeletal anomalies and, &euro, &trade, Nail-patella syndrome (NPS) is an autosomal dominant disorder characterized by dyplasia of finger nails, s disease |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the LMX1b/NPS1 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
LMX1b/NPS1 |
| Short name: |
LMX1b/NPS1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, LMX1b/NPS1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6654 |
| Gene: |
LMX1B |
More about : LMX1B |
| Long gene name: |
LIM homeobox transcription factor 1 beta |
| Synonyms gene: |
NPS1 |
| Synonyms gene name: |
LIM homeobox transcription factor 1, beta |
| Locus: |
9q33, 3 |
| Discovery year: |
1998-02-11 |
| GenBank acession: |
U77457 |
| Entrez gene record: |
4010 |
| Pubmed identfication: |
9441763 9590287 |
| Classification: |
LIM class homeoboxes |
| Havana BLAST/BLAT: |
OTTHUMG00000020692 |
| Locus Specific Databases: |
LRG_1014 |