| Long name: |
LMX1b/NPS1 Primary Polyclonal Antibody |
| Also known as: |
LMX1b/NPS1 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
LMX1b/NPS1 |
| Specificity: |
This is a highly specific antibody against LMX1b/NPS1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human LMX1b/NPS1 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
In addition, LMX1B along with LIM1 control the initial trajectory of motor axons in the developing mammalian limb, LMX1B belongs to the LIM-homeodomain family, LMX1B directly regulates the coordinated expression of alpha 3(IV) and alpha 4(IV) collagen required for normal glomerular basement membrane (GBM) morphogenesis, LMX1B is also necessary for normal development of the eye and in regulating dopaminergic neurogenesis and may be involved in developmental glaucoma and the aetiology of idiopathic Parkinsonâ, NPS is caused by putative loss-of-function mutations in the transcription factor LMX1B, Specifically, Twenty-two novel mutations may occur in the gene encoding LMX1B and the type and distribution of the mutations support the hypothesis that NPS is the result of haploinsufficiency for LMX1B, and the dysregulation of LMX1B in GBM contributes to the renal pathology and nephrosis in NPS, frequently, members of which are known to be important for pattern formation during development, renal disease, skeletal anomalies and, &euro, &trade, Nail-patella syndrome (NPS) is an autosomal dominant disorder characterized by dyplasia of finger nails, s disease |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
LIM homeobox transcription factor 1 beta, LIM homeobox transcription factor 1-beta, LIM-homeobox protein 1, LIM/homeobox protein 1, LIM/homeobox protein LMX1B, LMX 1, LMX-1, LMX1, LMX1B, LMX1B_HUMAN, NPS 1, NPS1, 2, 2, 2, 2, 2, LIM homeo box transcription factor 1 beta |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
LMX1b/NPS1 |
| Short name: |
LMX1b/NPS1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
LMX1b/NPS1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6654 |
| Gene: |
LMX1B |
More about : LMX1B |
| Long gene name: |
LIM homeobox transcription factor 1 beta |
| Synonyms gene: |
NPS1 |
| Synonyms gene name: |
LIM homeobox transcription factor 1, beta |
| Locus: |
9q33, 3 |
| Discovery year: |
1998-02-11 |
| GenBank acession: |
U77457 |
| Entrez gene record: |
4010 |
| Pubmed identfication: |
9441763 9590287 |
| Classification: |
LIM class homeoboxes |
| Havana BLAST/BLAT: |
OTTHUMG00000020692 |
| Locus Specific Databases: |
LRG_1014 |