| Long name: |
FITC Conjugated, ZFYVE27 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
ZFYVE27 |
| Specificity: |
This is a highly specific antibody against ZFYVE27 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human ZFYVE27 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Five isoforms of ZFYVE27 exist as a result of alternative splicing events, Mutations in the gene encoding ZFTVE27 affect neuronal intracellular trafficking in the corticospinal tract and are thought to lead to hereditary spastic paraplegia (HSP), The FYVE domain is a cysteine-rich domain of about 70 amino acids that plays a role in the endosomal localization of the FYVE-finger proteins, ZFYVE27, a multi-pass membrane protein, a neurodegenerative disorder, a protein that is primarily involved in microtubule dynamics and severing, also known as SPG33, and a majority of these proteins serve as regulators of endocytic membrane trafficking, characterized by progressive paralysis of the legs, is a 411 amino acid member of the FYVE-finger family of proteins, is an endosomal protein that binds to Spastin, vesicular trafficking and endosomal trafficking, which is caused by impaired axonal transport, Zinc finger FYVE domain-containing protein 27 (ZFYVE27) |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
FLJ32919 SPG33 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
ZFYVE27 Conjugated |
| Short name: |
FITC Conjugated, ZFYVE27 Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, ZFYVE27 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
26559 |
| Gene: |
ZFYVE27 |
More about : ZFYVE27 |
| Long gene name: |
zinc finger FYVE-type containing 27 |
| Synonyms gene name: |
FYVE domain containing 27 , zinc finger |
| Synonyms name: |
protrudin |
| Locus: |
10q24, 2 |
| Discovery year: |
2004-03-05 |
| GenBank acession: |
BC030621 |
| Entrez gene record: |
118813 |
| Pubmed identfication: |
14702039 |
| RefSeq identity: |
NM_144588 |
| Classification: |
Zinc fingers FYVE-type |
| Havana BLAST/BLAT: |
OTTHUMG00000018867 |