| Long name: |
ALEXA FLUOR 555 Conjugated, CLN8 Polyclonal Antibody |
| Also known as: |
Anti-CLN8 PAb ALEXA FLUOR 555 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
555, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
CLN8 |
| Specificity: |
This is a highly specific antibody against CLN8 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CLN8 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Both disorders are forms of neuronal ceroid-lipofuscinose (NCL), Mutations in the CLN8 gene cause neuronal ceroid lipofuscinosis 8 and progressive epilepsy with mental retardation (EPMR), The CLN8 protein is one of eight proteins in the CLN family, a 286 amino acid transmembrane protein, a group of progressive neurodegenerative diseases found in children, but also partially to the ER-Golgi intermediate compartment (ERGIC), characterized by failure of psychomotor development, impaired vision, including CLN1-CLN7, localizes mainly to the endoplasmic reticulum, seizures and premature death, which are associated with NCL, CLN8 |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
553nm/568nm |
| Synonyms: |
FLJ39417 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 555, Alexa Fluor |
| Gene target: |
CLN8 |
| Short name: |
CLN8 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 555 |
| Alternative name: |
ALEXA FLUOR 555, neuronal 8 (epilepsy, progressive with mental retardation) (Antibody to), ceroid-lipofuscinosis |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
C8orf61 and EPMR, CLN8 and IDBG-5421 and ENSG00000182372 and 2055, CLN8 and IDBG-628376 and ENSBTAG00000008584 and 530874, Cln8 and IDBG-136384 and ENSMUSG00000026317 and 26889, Plasma membranes, neuronal 8 (epilepsy, progressive with mental retardation), this GO :0001306 and age-dependent response to oxidative stress and biological process this GO :0005739 and mitochondrion and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005789 and endoplasmic reticulum membrane and cellular component this GO :0005793 and endoplasmic reticulum- this GO lgi intermediate compartment and cellular component this GO :0006644 and phospholipid metabolic process and biological process this GO :0006672 and ceramide metabolic process and biological process this GO :0006869 and lipid transport and biological process this GO :0007006 and mitochondrial membrane organization and biological process this GO :0007040 and lysosome organization and biological process this GO :0007399 and nervous system development and biological process this GO :0007601 and visual perception and biological process this GO :0007628 and adult walking behavior and biological process this GO :0008203 and cholesterol metabolic process and biological process this GO :0008219 and cell death and biological process this GO :0008306 and associative learning and biological process this GO :0008344 and adult locomotory behavior and biological process this GO :0008361 and regulation of cell size and biological process this GO :0008610 and lipid biosynthetic process and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0021522 and spinal cord motor neuron differentiation and biological process this GO :0021523 and somatic motor neuron differentiation and biological process this GO :0030163 and protein catabolic process and biological process this GO :0033116 and endoplasmic reticulum- this GO lgi intermediate compartment membrane and cellular component this GO :0035176 and social behavior and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0044257 and cellular protein catabolic process and biological process this GO :0044265 and cellular macromolecule catabolic process and biological process this GO :0044267 and cellular protein metabolic process and biological process this GO :0045494 and photoreceptor cell maintenance and biological process this GO :0045861 and negative regulation of proteolysis and biological process this GO :0046513 and ceramide biosynthetic process and biological process this GO :0050881 and musculoskeletal movement and biological process this GO :0050884 and neuromuscular process controlling posture and biological process this GO :0050885 and neuromuscular process controlling balance and biological process this GO :0051348 and negative regulation of transferase activity and biological process this GO :0051935 and L-glutamate uptake involved in synaptic transmission and biological process this GO :0060041 and retina development in camera-type eye and biological process this GO :0060052 and neurofilament cytoskeleton organization and biological process, ceroid-lipofuscinosis |
| Identity: |
2079 |
| Gene: |
CLN8 |
More about : CLN8 |
| Long gene name: |
ceroid-lipofuscinosis, neuronal 8 |
| Synonyms gene: |
EPMR C8orf61 |
| Synonyms gene name: |
chromosome 8 open reading frame 61 epilepsy, progressive with mental retardation |
| Locus: |
8p23, 3 |
| Discovery year: |
1993-12-15 |
| GenBank acession: |
AF123761 |
| Entrez gene record: |
2055 |
| Pubmed identfication: |
10508524 23160995 |
| RefSeq identity: |
NM_018941 |
| Classification: |
TLC domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000090343 |
| Locus Specific Databases: |
NCL Mutations LRG_691 , Neuronal Ceroid Lipofuscinoses |