| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
CLN8 |
| Specificity: |
This antibody reacts specifically with CLN8 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human CLN8 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Both disorders are forms of neuronal ceroid-lipofuscinose (NCL), Mutations in the CLN8 gene cause neuronal ceroid lipofuscinosis 8 and progressive epilepsy with mental retardation (EPMR), The CLN8 protein is one of eight proteins in the CLN family, a 286 amino acid transmembrane protein, a group of progressive neurodegenerative diseases found in children, but also partially to the ER-Golgi intermediate compartment (ERGIC), characterized by failure of psychomotor development, impaired vision, including CLN1-CLN7, localizes mainly to the endoplasmic reticulum, seizures and premature death, which are associated with NCL, CLN8 |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
FLJ39417 |
| Also known as: |
CLN8 Polyclonal Antibody |
| Other name: |
Anti-CLN8 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
CLN8 |
| Short name: |
Anti-CLN8 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, neuronal 8 (epilepsy, progressive with mental retardation) (polyclonal), antibody to-ceroid-lipofuscinosis |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
C8orf61 and EPMR, CLN8 and IDBG-5421 and ENSG00000182372 and 2055, CLN8 and IDBG-628376 and ENSBTAG00000008584 and 530874, Cln8 and IDBG-136384 and ENSMUSG00000026317 and 26889, Plasma membranes, neuronal 8 (epilepsy, progressive with mental retardation), this GO :0001306 and age-dependent response to oxidative stress and biological process this GO :0005739 and mitochondrion and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005789 and endoplasmic reticulum membrane and cellular component this GO :0005793 and endoplasmic reticulum- this GO lgi intermediate compartment and cellular component this GO :0006644 and phospholipid metabolic process and biological process this GO :0006672 and ceramide metabolic process and biological process this GO :0006869 and lipid transport and biological process this GO :0007006 and mitochondrial membrane organization and biological process this GO :0007040 and lysosome organization and biological process this GO :0007399 and nervous system development and biological process this GO :0007601 and visual perception and biological process this GO :0007628 and adult walking behavior and biological process this GO :0008203 and cholesterol metabolic process and biological process this GO :0008219 and cell death and biological process this GO :0008306 and associative learning and biological process this GO :0008344 and adult locomotory behavior and biological process this GO :0008361 and regulation of cell size and biological process this GO :0008610 and lipid biosynthetic process and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0021522 and spinal cord motor neuron differentiation and biological process this GO :0021523 and somatic motor neuron differentiation and biological process this GO :0030163 and protein catabolic process and biological process this GO :0033116 and endoplasmic reticulum- this GO lgi intermediate compartment membrane and cellular component this GO :0035176 and social behavior and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0044257 and cellular protein catabolic process and biological process this GO :0044265 and cellular macromolecule catabolic process and biological process this GO :0044267 and cellular protein metabolic process and biological process this GO :0045494 and photoreceptor cell maintenance and biological process this GO :0045861 and negative regulation of proteolysis and biological process this GO :0046513 and ceramide biosynthetic process and biological process this GO :0050881 and musculoskeletal movement and biological process this GO :0050884 and neuromuscular process controlling posture and biological process this GO :0050885 and neuromuscular process controlling balance and biological process this GO :0051348 and negative regulation of transferase activity and biological process this GO :0051935 and L-glutamate uptake involved in synaptic transmission and biological process this GO :0060041 and retina development in camera-type eye and biological process this GO :0060052 and neurofilament cytoskeleton organization and biological process, ceroid-lipofuscinosis |
| Identity: |
2079 |
| Gene: |
CLN8 |
More about : CLN8 |
| Long gene name: |
ceroid-lipofuscinosis, neuronal 8 |
| Synonyms gene: |
EPMR C8orf61 |
| Synonyms gene name: |
chromosome 8 open reading frame 61 epilepsy, progressive with mental retardation |
| Locus: |
8p23, 3 |
| Discovery year: |
1993-12-15 |
| GenBank acession: |
AF123761 |
| Entrez gene record: |
2055 |
| Pubmed identfication: |
10508524 23160995 |
| RefSeq identity: |
NM_018941 |
| Classification: |
TLC domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000090343 |
| Locus Specific Databases: |
NCL Mutations LRG_691 , Neuronal Ceroid Lipofuscinoses |