| Long name: |
Biotin Conjugated, AIP1 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
AIP1 |
| Specificity: |
This is a highly specific antibody against AIP1 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human AIP1 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
AIP1 exists as multiple alternatively spliced isoforms and is down-regulated in prostate cancer tissue, AIP1 functions as a Ras GTPase-activating protein that interacts with ASK 1 and, Chromosomal aberrations in the gene encoding AIP1 are associated with acute myeloid leukemia (AML), Expressed at low levels in prostate tissue, also known as DAB2IP (DAB2 interacting protein), disrupts the association of ASK 1 with an inhibitory 14-3-3 complex, implicating a role for AIP1 fusion proteins in tumorigenesis, is a 1, one PH domain and one C2 domain, suggesting a role in tumor suppression, thereby allowing free ASK 1 to function within the cell, via this interaction, 189 amino acid protein that localizes to both the membrane and the cytoplasm and contains one Ras-GAP domain, AIP1 (ASK-interacting protein 1) |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
Alix AIP1 Hp95 |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
AIP1 Conjugated |
| Short name: |
Conjugated, AIP1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, AIP1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8766 |
| Gene: |
PDCD6IP |
More about : PDCD6IP |
| Long gene name: |
programmed cell death 6 interacting protein |
| Synonyms gene name: |
programmed cell death 6-interacting protein |
| Synonyms name: |
ALG-2 interacting protein X |
| Locus: |
3p22, 3 |
| Discovery year: |
1999-12-10 |
| GenBank acession: |
BC020066 |
| Entrez gene record: |
10015 |
| Pubmed identfication: |
9880530 |
| Havana BLAST/BLAT: |
OTTHUMG00000130751 |