| Long name: |
HRP Conjugated, Gemin 3/SMA Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
HRP Conjugated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Gemin 3/SMA |
| Specificity: |
This is a highly specific antibody against Gemin 3/SMA |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human Gemin 3 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
DDX20, DEAD-box protein DP130 and DEAD/H box 20, Gemin3, Gemin3 also interacts with SmB, Gemin3 is a putative RNA helicase and shows ATPase activity, Gemin4, Gemin5 and Gemin6, It associates directly with SMN and is a part of the SMN complex containing Gemin2, It contains the conserved motif Asp-Glu-Ala-Asp (DEAD) characteristic of DEAD-box proteins, It is expressed in B and T cell neuroblastoma-derived cell lines, It is found in both the cytoplasm and the nucleus, SMA is caused by deletion or loss-of-function mutations in the SMN (survival of motor neuron) gene, SmD2 and SmD3, The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing of the nucleus, The nuclear form is concentrated in subnuclear bodies called gems (for Gemini of the coiled bodies), also known as DP103, as well as several spliceosomal snRNP proteins, is a protein product of human chromosome 1p13, kidney and lung, liver, malignant melanoma tumor, normal testis and is expressed in low levels in colon, skeletal muscle, 2, Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease characterized by loss of motor neurons in the spinal cord |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% Gentamicin, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
BCD541 SMNT SMA1 SMA2 SMA3 GEMIN1 TDRD16A |
| Properties: |
Also monoclonal HRP conjugates are often used for Western Blot, HRP conjugates are often primary rabbit polyclonal antibodies couples to the , found in the roots of , (HRP), C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°, enzyme , horseradish, horseradish peroxidase |
| Gene target: |
Gemin 3/SMA Conjugated |
| Short name: |
Conjugated, Gemin 3/SMA Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
HRP |
| Alternative name: |
horseradish peroxidase coupled, Gemin 3/SMA (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11117 |
| Gene: |
SMN1 |
More about : SMN1 |
| Long gene name: |
survival of motor neuron 1, telomeric |
| Synonyms gene: |
SMA@ SMA |
| Synonyms gene name: |
Kugelberg-Welander disease) , spinal muscular atrophy (Werdnig-Hoffmann disease |
| Synonyms name: |
gemin-1 tudor domain containing 16A |
| Locus: |
5q13, 2 |
| Discovery year: |
1996-12-12 |
| GenBank acession: |
U18423 |
| Entrez gene record: |
6606 |
| Pubmed identfication: |
7813012 |
| RefSeq identity: |
NM_000344 |
| Classification: |
Tudor domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000099361 |
| Locus Specific Databases: |
SMN1 - Spinal Muscular Atrophy (SMA) Leiden Muscular Dystrophy pages ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database LRG_676 |