| Long name: |
TPOR Primary Polyclonal Antibody |
| Also known as: |
TPOR PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
TPOR |
| Specificity: |
This is a highly specific antibody against TPOR |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TPOR |
| Tested Applications: |
FCM, IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
FCM(1:20-100), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Expression of c-Mpl is restricted to hematopoietic tissues and cells, Muta-tions in c-Mpl have been implicated as the cause of certain human disorders, Stimulation of c-Mpl with TPO results in the activation of the Janus tyrosine kinase family members, TPO exerts its biological effects through the TPO receptor, Tyk 2 and JAK2, also known as c-Mpl ligand (c-Mpl L), c-Mpl, c-Mpl is a member of the cytokine receptor superfamily, causing their nuclear translocation and the transcription of Stat responsive genes, fetal liver and CD34+ cells, including congenital amegakaryocytic thrombocytopenia (CAMT) and thrombocytopenia with absent radii (TAR) syndrome, is a cytokine that plays a central role in megakaryopoiesis by influencing the development and maturation of megakaryocytes and platelet production from hematopoietic stem cells, spleen, such as bone marrow, which in turn phosphorylate Stat5 and Stat3, Thrombopoietin (TPO or THPO) |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
C-MPL, CD 110, CD110, CMPL, MPL, MPLV, Myeloprolerative leukemia protein, Myeloprolerative leukemia virus oncogene, Proto-oncogene c-Mpl, THCYT2, TPO R, TPO-R, TPOR, TPOR_HUMAN, Thrombopoietin receptor, C MPL |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
TPOR |
| Short name: |
TPOR Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TPOR (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
7217 |
| Gene: |
MPL |
More about : MPL |
| Long gene name: |
MPL proto-oncogene, thrombopoietin receptor |
| Synonyms gene name: |
myeloproliferative leukemia virus oncogene |
| Synonyms: |
CD110 TPOR |
| Locus: |
1p34, 2 |
| Discovery year: |
1990-09-10 |
| GenBank acession: |
M90102 |
| Entrez gene record: |
4352 |
| Pubmed identfication: |
1608974 |
| RefSeq identity: |
NM_005373 |
| Classification: |
CD molecules Fibronectin type III domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000007429 |
| Locus Specific Databases: |
LRG_510 |