| Long name: |
ALEXA FLUOR 647 Conjugated, MYO6/Myosin VI Polyclonal Antibody |
| Also known as: |
Anti-MYO6/Myosin VI PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
MYO6/Myosin VI |
| Specificity: |
This is a highly specific antibody against MYO6/Myosin VI |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Myosin VI |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Defects of Myosin VI cause autosomal dominant nonsyndromic sensori-neural deafness in humans, Human Myosin VI is expressed in fetal cochlea and brain, Human Myosin VI is mapped to the centromeric region of chromosome 6, It associates with Clathrin-coated vesicles and disabled 2, Mouse Myosin VI is expressed within the sensory hair cells of the cochlea, The behavioral effects of the mouse Snellâ, This unique Myosin has only one light chain in the lever-arm domain and has highly irregular stepping with a wide range of step sizes, a region that shows syntenic homology with the corresponding mouse chromosome 9 region, as well as in adult brain, due to the disorganization and fusing of stereocilia bundles within the inner ear, head tossing and circling, hyperactivity, indicating a role for Myosin VI in endocytosis, is the only Myosin motor that binds to the pointed end of Actin, unlike that of other characterized Myosins, where the Snellâ, &euro, &euro, &trade, &trade, Myosin VI a molecular motor involved in intracellular vesicle and organelle transport, s Waltzer mutation are lack of responsiveness to sound, s Waltzer mutation is located |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
KIAA0389 |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the MYO6/Myosin VI Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
MYO6/Myosin VI |
| Short name: |
MYO6/Myosin VI Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, myosin VI/Myosin VI (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DFNA22 and DFNB37, MYO6 and IDBG-629903 and ENSBTAG00000016751 and 535127, MYO6 and IDBG-93156 and ENSG00000196586 and 4646, Myo6 and IDBG-187852 and ENSMUSG00000033577 and 17920, holoenzyme and cellular component this GO :0030048 and actin filament-based movement and biological process this GO :0030139 and endocytic vesicle and cellular component this GO :0030330 and DNA damage response, minus-end directed microfilament motor activity, nuclei, signal transduction by p53 class mediator and biological process this GO :0030424 and axon and cellular component this GO :0030665 and clathrin-coated vesicle membrane and cellular component this GO :0031941 and filamentous actin and cellular component this GO :0031965 and nuclear membrane and cellular component this GO :0032587 and ruffle membrane and cellular component this GO :0042472 and inner ear morphogenesis and biological process this GO :0042491 and auditory receptor cell differentiation and biological process this GO :0042493 and response to drug and biological process this GO :0043025 and neuronal cell body and cellular component this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0043234 and protein complex and cellular component this GO :0043531 and ADP binding and molecular function this GO :0045177 and apical part of cell and cellular component this GO :0045334 and clathrin-coated endocytic vesicle and cellular component this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048167 and regulation of synaptic plasticity and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0048839 and inner ear development and biological process this GO :0051015 and actin filament binding and molecular function this GO :0051046 and regulation of secretion and biological process this GO :0060001 and minus-end directed microfilament motor activity and molecular function this GO :0061024 and membrane organization and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0071257 and cellular response to electrical stimulus and biological process, this GO :0001726 and ruffle and cellular component this GO :0003774 and motor activity and molecular function this GO :0003779 and actin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005516 and calmodulin binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005765 and lysosomal membrane and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005902 and microvillus and cellular component this GO :0005905 and coated pit and cellular component this GO :0005938 and cell cortex and cellular component this GO :0006605 and protein targeting and biological process this GO :0006886 and intracellular protein transport and biological process this GO :0006897 and endocytosis and biological process this GO :0007268 and synaptic transmission and biological process this GO :0007416 and synapse assembly and biological process this GO :0007605 and sensory perception of sound and biological process this GO :0007626 and locomotory behavior and biological process this GO :0008152 and metabolic process and biological process this GO :0012506 and vesicle membrane and cellular component this GO :0014047 and glutamate secretion and biological process this GO :0016020 and membrane and cellular component this GO :0016023 and cytoplasmic membrane-bounded vesicle and cellular component this GO :0016358 and dendrite development and biological process this GO :0016459 and myosin complex and cellular component this GO :0016461 and unconventional myosin complex and cellular component this GO :0016591 and DNA-directed RNA polymerase II, this GO :0003774 : motor activity, this GO :0003774 : motor activity and also this GO :0003779 : actin binding and also this GO :0005515 : protein binding and also this GO :0005516 : calmodulin binding and also this GO :0005524 : ATP binding and also this GO :0043531 : ADP binding and also this GO :0051015 : actin filament binding and also this GO :0060001 : minus-end directed microfilament motor activity, this GO :0003779 : actin binding, this GO :0005515 : protein binding, this GO :0005516 : calmodulin binding, this GO :0005524 : ATP binding, this GO :0043531 : ADP binding, this GO :0051015 : actin filament binding, this GO :0060001 : minus-end directed microfilament motor activity, myosin VI |
| Identity: |
7605 |
| Gene: |
MYO6 |
More about : MYO6 |
| Long gene name: |
myosin VI |
| Synonyms gene: |
DFNA22 DFNB37 |
| Synonyms gene name: |
autosomal recessive 37 , deafness |
| Locus: |
6q14, 1 |
| Discovery year: |
1996-04-04 |
| GenBank acession: |
U90236 AB002387 |
| Entrez gene record: |
4646 |
| Pubmed identfication: |
9259267 11468689 |
| RefSeq identity: |
NM_004999 |
| Classification: |
Myosins, class VI Deafness associated genes |
| Havana BLAST/BLAT: |
OTTHUMG00000015061 |
| Locus Specific Databases: |
Hereditary Hearing Loss Homepage CCHMC-BMI &, UC Hearing Loss Mutation Database LRG_438 |