| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
MYO6/Myosin VI |
| Specificity: |
This antibody reacts specifically with MYO6/Myosin VI |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Myosin VI |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Defects of Myosin VI cause autosomal dominant nonsyndromic sensori-neural deafness in humans, Human Myosin VI is expressed in fetal cochlea and brain, Human Myosin VI is mapped to the centromeric region of chromosome 6, It associates with Clathrin-coated vesicles and disabled 2, Mouse Myosin VI is expressed within the sensory hair cells of the cochlea, The behavioral effects of the mouse Snellâ, This unique Myosin has only one light chain in the lever-arm domain and has highly irregular stepping with a wide range of step sizes, a region that shows syntenic homology with the corresponding mouse chromosome 9 region, as well as in adult brain, due to the disorganization and fusing of stereocilia bundles within the inner ear, head tossing and circling, hyperactivity, indicating a role for Myosin VI in endocytosis, is the only Myosin motor that binds to the pointed end of Actin, unlike that of other characterized Myosins, where the Snellâ, &euro, &euro, &trade, &trade, Myosin VI a molecular motor involved in intracellular vesicle and organelle transport, s Waltzer mutation are lack of responsiveness to sound, s Waltzer mutation is located |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
KIAA0389 |
| Also known as: |
MYO6/Myosin VI Polyclonal Antibody |
| Other name: |
Anti-MYO6/Myosin VI Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
MYO6/Myosin VI |
| Short name: |
Anti-MYO6/Myosin VI (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-myosin VI/Myosin VI (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
DFNA22 and DFNB37, MYO6 and IDBG-629903 and ENSBTAG00000016751 and 535127, MYO6 and IDBG-93156 and ENSG00000196586 and 4646, Myo6 and IDBG-187852 and ENSMUSG00000033577 and 17920, holoenzyme and cellular component this GO :0030048 and actin filament-based movement and biological process this GO :0030139 and endocytic vesicle and cellular component this GO :0030330 and DNA damage response, minus-end directed microfilament motor activity, nuclei, signal transduction by p53 class mediator and biological process this GO :0030424 and axon and cellular component this GO :0030665 and clathrin-coated vesicle membrane and cellular component this GO :0031941 and filamentous actin and cellular component this GO :0031965 and nuclear membrane and cellular component this GO :0032587 and ruffle membrane and cellular component this GO :0042472 and inner ear morphogenesis and biological process this GO :0042491 and auditory receptor cell differentiation and biological process this GO :0042493 and response to drug and biological process this GO :0043025 and neuronal cell body and cellular component this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0043234 and protein complex and cellular component this GO :0043531 and ADP binding and molecular function this GO :0045177 and apical part of cell and cellular component this GO :0045334 and clathrin-coated endocytic vesicle and cellular component this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048167 and regulation of synaptic plasticity and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0048839 and inner ear development and biological process this GO :0051015 and actin filament binding and molecular function this GO :0051046 and regulation of secretion and biological process this GO :0060001 and minus-end directed microfilament motor activity and molecular function this GO :0061024 and membrane organization and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0071257 and cellular response to electrical stimulus and biological process, this GO :0001726 and ruffle and cellular component this GO :0003774 and motor activity and molecular function this GO :0003779 and actin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005516 and calmodulin binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005765 and lysosomal membrane and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005902 and microvillus and cellular component this GO :0005905 and coated pit and cellular component this GO :0005938 and cell cortex and cellular component this GO :0006605 and protein targeting and biological process this GO :0006886 and intracellular protein transport and biological process this GO :0006897 and endocytosis and biological process this GO :0007268 and synaptic transmission and biological process this GO :0007416 and synapse assembly and biological process this GO :0007605 and sensory perception of sound and biological process this GO :0007626 and locomotory behavior and biological process this GO :0008152 and metabolic process and biological process this GO :0012506 and vesicle membrane and cellular component this GO :0014047 and glutamate secretion and biological process this GO :0016020 and membrane and cellular component this GO :0016023 and cytoplasmic membrane-bounded vesicle and cellular component this GO :0016358 and dendrite development and biological process this GO :0016459 and myosin complex and cellular component this GO :0016461 and unconventional myosin complex and cellular component this GO :0016591 and DNA-directed RNA polymerase II, this GO :0003774 : motor activity, this GO :0003774 : motor activity and also this GO :0003779 : actin binding and also this GO :0005515 : protein binding and also this GO :0005516 : calmodulin binding and also this GO :0005524 : ATP binding and also this GO :0043531 : ADP binding and also this GO :0051015 : actin filament binding and also this GO :0060001 : minus-end directed microfilament motor activity, this GO :0003779 : actin binding, this GO :0005515 : protein binding, this GO :0005516 : calmodulin binding, this GO :0005524 : ATP binding, this GO :0043531 : ADP binding, this GO :0051015 : actin filament binding, this GO :0060001 : minus-end directed microfilament motor activity, myosin VI |
| Identity: |
7605 |
| Gene: |
MYO6 |
More about : MYO6 |
| Long gene name: |
myosin VI |
| Synonyms gene: |
DFNA22 DFNB37 |
| Synonyms gene name: |
autosomal recessive 37 , deafness |
| Locus: |
6q14, 1 |
| Discovery year: |
1996-04-04 |
| GenBank acession: |
U90236 AB002387 |
| Entrez gene record: |
4646 |
| Pubmed identfication: |
9259267 11468689 |
| RefSeq identity: |
NM_004999 |
| Classification: |
Myosins, class VI Deafness associated genes |
| Havana BLAST/BLAT: |
OTTHUMG00000015061 |
| Locus Specific Databases: |
Hereditary Hearing Loss Homepage CCHMC-BMI &, UC Hearing Loss Mutation Database LRG_438 |