| Long name: |
RPA70 Primary Polyclonal Antibody |
| Also known as: |
RPA70 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
RPA70 |
| Specificity: |
This is a highly specific antibody against RPA70 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human RPA70 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
It can also play a role in telomere maintenance, RPA contains a conserved four cysteine-type zinc-finger motif, RPA is a major damage-recognition protein involved in the early stages of nucleotide excision repair, RPA plays an important role in DNA replication, Replication protein A (RPA), The DNA binding domain lies in the middle of RPA 70 kDa subunit and comprises two structurally homologous subdomains oriented in tandem, The RPA 70 kDa subunit binds to ssDNA and mediates interactions with many cellular and viral proteins, The binding of human RPA (hRPA) to DNA involves molecular polarity in which initial hRPA binding occurs on the 5' side of an ssDNA substrate and then extends in the 3' direction to create a stably bound hRPA, a highly conserved eukaryotic protein, is a heterotrimeric SSB, mitochondria, phages and viruses, recombination and repair, which mediates the transition of RPA-ssDNA interaction to a stable RPA-ssDNA complex in a redox-dependent manner, The single-stranded-DNA-binding proteins (SSBs) are essential for DNA function in prokaryotic and eukaryotic cells |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
DRPA, Drosophila Replication Protein A, HSSB, Human single stranded DNA binding protein, MST075, MSTP075, RF A, RF-A protein 1, RFA, RFA1_HUMAN, RP A, RP-A p70, RPA, RPA 70, RPA1, Replication factor A, Replication factor A protein 1, Replication protein A 70 kDa DNA-binding subunit, Replication protein A 70kDa DNA binding subunit, Replication protein A1, Replication protein A1 70kDa, Single stranded binding protein 70, Single-stranded DNA-binding protein, p70 antibody REPA1, Dmrpa1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
RPA70 |
| Short name: |
RPA70 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
RPA70 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
10289 |
| Gene: |
RPA1 |
More about : RPA1 |
| Long gene name: |
replication protein A1 |
| Synonyms gene name: |
70kDa , replication protein A1 (70kD) replication protein A1 |
| Synonyms: |
REPA1 RPA70 HSSB RF-A RP-A |
| Locus: |
17p13, 3 |
| Discovery year: |
1993-12-14 |
| GenBank acession: |
M63488 |
| Entrez gene record: |
6117 |
| Pubmed identfication: |
8454588 |
| RefSeq identity: |
NM_002945 |
| Classification: |
Nucleotide excision repair |
| Havana BLAST/BLAT: |
OTTHUMG00000090579 |