| Long name: |
ALEXA FLUOR 488 Conjugated, Exportin 5 Polyclonal Antibody |
| Also known as: |
Anti-Exportin 5 PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Exportin 5 |
| Specificity: |
This is a highly specific antibody against Exportin 5 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Exportin 5 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
More recently, Research studies have shown disruption of exportin 5 functions in many types of cancers including breast and lung, Study of the miRNA biosynthesis pathway is essential in understanding the process of oncogenesis as global downregulation of miRNAs and the resulting alterations in the expression of tumor suppressor and oncogenic proteins is a common phenotype of cancers cells , family of proteins and functions in tRNA export in a sequence dependent fashion, it has been shown to export pre-miRNA by a RanGTPase-driven process from the nucleus to the cytoplasm, where pre-miRNA accumulates in the nucleus and miRNA maturation is impaired, where pre-miRNA processing occurs to produce mature miRNAs, ², Exportin 5 (XPO5) is a member of the importin Î |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
KIAA1291 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the Exportin 5 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
Exportin 5 |
| Short name: |
Exportin 5 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, Exportin 5 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
17675 |
| Gene: |
XPO5 |
More about : XPO5 |
| Long gene name: |
exportin 5 |
| Locus: |
6p21, 1 |
| Discovery year: |
2003-03-10 |
| GenBank acession: |
AB033117 |
| Entrez gene record: |
57510 |
| Pubmed identfication: |
11777942 12426392 |
| RefSeq identity: |
NM_020750 |
| Classification: |
Exportins |
| Havana BLAST/BLAT: |
OTTHUMG00000014742 |