| Long name: |
Cy5, 5 Conjugated, MTMR14 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Cy5, 5, 5, Cy5 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
MTMR14 |
| Specificity: |
This is a highly specific antibody against MTMR14 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human MTMR14 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
In these studies, In zebrafish, MTMR14 deficiency in mice leads to altered calcium homeostasis and muscle disorders (2), MTMR14 has also been shown to play a role in autophagy, MTMR14 inhibited autophagy and mutations of MTMR14 associated with centronuclear myopathy were also defective in autophagy inhibition, MTMR14 knockdown was shown to increase the number of autophagosomes, MTMR14 was localized to autophagic isolation membranes and early autophagosomes (3), Mutations in the MTMR14 gene have been associated with centronuclear myopathy (1), Vps34 (3), a process that is highly regulated by phosphatidylinositides through the type III PI3K, also known as Jumpy, is a myotubularin-related phosphoinositol-3-phosphate (PI3P) phosphatase (1), suggesting that its activity is associated with an inhibition of autophagy (4), Myotubularin-related protein 14 (MTMR14) |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
675nm/694nm |
| Synonyms: |
FLJ22405 FLJ90311 hJumpy hEDTP |
| Properties: |
Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Conjugated: |
These antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths |
| Gene target: |
MTMR14 Conjugated |
| Short name: |
Conjugated, MTMR14 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
5, Cy5 |
| Alternative name: |
cyanine 5, 5 coupled, MTMR14 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
26190 |
| Gene: |
MTMR14 |
More about : MTMR14 |
| Long gene name: |
myotubularin related protein 14 |
| Synonyms gene: |
C3orf29 |
| Synonyms gene name: |
chromosome 3 open reading frame 29 |
| Synonyms name: |
egg-derived tyrosine phosphatase homolog (Drosophila) |
| Locus: |
3p25, 3 |
| Discovery year: |
2005-12-22 |
| GenBank acession: |
BC001674 |
| Entrez gene record: |
64419 |
| Pubmed identfication: |
15186772 |
| RefSeq identity: |
NM_022485 |
| Classification: |
Phosphoinositide phosphatases Myotubularins |
| Havana BLAST/BLAT: |
OTTHUMG00000155111 |