| Long name: |
ALEXA FLUOR 594 Conjugated, MTMR14 Polyclonal Antibody |
| Also known as: |
Anti-MTMR14 PAb ALEXA FLUOR 594 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
MTMR14 |
| Specificity: |
This is a highly specific antibody against MTMR14 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MTMR14 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
In these studies, In zebrafish, MTMR14 deficiency in mice leads to altered calcium homeostasis and muscle disorders (2), MTMR14 has also been shown to play a role in autophagy, MTMR14 inhibited autophagy and mutations of MTMR14 associated with centronuclear myopathy were also defective in autophagy inhibition, MTMR14 knockdown was shown to increase the number of autophagosomes, MTMR14 was localized to autophagic isolation membranes and early autophagosomes (3), Mutations in the MTMR14 gene have been associated with centronuclear myopathy (1), Vps34 (3), a process that is highly regulated by phosphatidylinositides through the type III PI3K, also known as Jumpy, is a myotubularin-related phosphoinositol-3-phosphate (PI3P) phosphatase (1), suggesting that its activity is associated with an inhibition of autophagy (4), Myotubularin-related protein 14 (MTMR14) |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
FLJ22405 FLJ90311 hJumpy hEDTP |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
594, ALEXA FLUOR®, Alexa Fluor |
| Conjugated: |
Alexa conjugate 1 |
| Gene target: |
MTMR14 |
| Short name: |
MTMR14 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 594 |
| Alternative name: |
ALEXA FLUOR 594, MTMR14 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
26190 |
| Gene: |
MTMR14 |
More about : MTMR14 |
| Long gene name: |
myotubularin related protein 14 |
| Synonyms gene: |
C3orf29 |
| Synonyms gene name: |
chromosome 3 open reading frame 29 |
| Synonyms name: |
egg-derived tyrosine phosphatase homolog (Drosophila) |
| Locus: |
3p25, 3 |
| Discovery year: |
2005-12-22 |
| GenBank acession: |
BC001674 |
| Entrez gene record: |
64419 |
| Pubmed identfication: |
15186772 |
| RefSeq identity: |
NM_022485 |
| Classification: |
Phosphoinositide phosphatases Myotubularins |
| Havana BLAST/BLAT: |
OTTHUMG00000155111 |