| Long name: |
ALEXA FLUOR 488 Conjugated, SUFU/Suppressor of Fused Antibody |
| Also known as: |
Anti-SUFU/Suppressor of Fused PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
SUFU/Suppressor of Fused |
| Specificity: |
This is a highly specific antibody against SUFU/Suppressor of Fused |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
440-484/484 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SUFU |
| Gene ID Number: |
51684 |
| Swiss Prot: |
Q9UMX1 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Down-regulates GLI1-mediated transactivation of target genes, GLI2 and GLI3 in the cytoplasm, GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state, May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome, Negative regulator of beta-catenin signaling, Part of a corepressor complex that acts on DNA-bound GLI1, Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full length form of GLI3 (GLI3FL), Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity), SUFU dissociates from GLI3FL and the latter translocates to the nucleus, Sequesters GLI1, When Hh signaling is initiated, Without the Hh signal, and converted to a transcriptional activator (GLI3A), destabilized, leading to the efficient processing of GLI3FL into GLI3R, the SUFU-GLI3 complex is recruited to cilia, this effect is overcome by binding of STK36 to both SUFU and a GLI protein, where it is phosphorylated, Negative regulator in the hedgehog signaling pathway |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
SUFUH SUFUXL PRO1280 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the SUFU/Suppressor of Fused Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Description: |
HRAS like - suppressor protein make genetic suppression restoring the phenotype seen prior to the original background in , breast cancer tumor, Kinase, biological pathways |
| Gene target: |
SUFU/Suppressor of Fused |
| Short name: |
SUFU/Suppressor of Fused Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, SUFU/Suppressor on Fused (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
16466 |
| Gene: |
SUFU |
More about : SUFU |
| Long gene name: |
SUFU negative regulator of hedgehog signaling |
| Synonyms gene name: |
suppressor of fused homolog (Drosophila) |
| Locus: |
10q24, 32 |
| Discovery year: |
2001-08-28 |
| GenBank acession: |
AF175770 |
| Entrez gene record: |
51684 |
| Pubmed identfication: |
15367681 |
| RefSeq identity: |
NM_016169 |
| Havana BLAST/BLAT: |
OTTHUMG00000018966 |
| Locus Specific Databases: |
LRG_521 |