| Long name: |
SUFU/Suppressor of Fused Antibody |
| Also known as: |
SUFU/Suppressor of Fused Antibody |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
SUFU/Suppressor of Fused |
| Specificity: |
This is a highly specific antibody against SUFU/Suppressor of Fused |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
440-484/484 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SUFU |
| Gene ID number: |
51684 |
| Swiss Prot: |
Q9UMX1 |
| Tested Applications: |
IF(IHC-P), IHC-P |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Down-regulates GLI1-mediated transactivation of target genes, GLI2 and GLI3 in the cytoplasm, GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state, May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome, Negative regulator of beta-catenin signaling, Part of a corepressor complex that acts on DNA-bound GLI1, Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full length form of GLI3 (GLI3FL), Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity), SUFU dissociates from GLI3FL and the latter translocates to the nucleus, Sequesters GLI1, When Hh signaling is initiated, Without the Hh signal, and converted to a transcriptional activator (GLI3A), destabilized, leading to the efficient processing of GLI3FL into GLI3R, the SUFU-GLI3 complex is recruited to cilia, this effect is overcome by binding of STK36 to both SUFU and a GLI protein, where it is phosphorylated, Negative regulator in the hedgehog signaling pathway |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
PRO1280, SUFU, SUFUXL, Suppressor of fused homolog, UNQ650/PRO1280, SUFUH |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Description: |
HRAS like - suppressor protein make genetic suppression restoring the phenotype seen prior to the original background in , breast cancer tumor, Kinase, biological pathways |
| Gene target: |
SUFU/Suppressor of Fused |
| Short name: |
SUFU/Suppressor of Fused Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
SUFU/Suppressor on Fused (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
16466 |
| Gene: |
SUFU |
More about : SUFU |
| Long gene name: |
SUFU negative regulator of hedgehog signaling |
| Synonyms gene name: |
suppressor of fused homolog (Drosophila) |
| Synonyms: |
SUFUH SUFUXL PRO1280 |
| Locus: |
10q24, 32 |
| Discovery year: |
2001-08-28 |
| GenBank acession: |
AF175770 |
| Entrez gene record: |
51684 |
| Pubmed identfication: |
15367681 |
| RefSeq identity: |
NM_016169 |
| Havana BLAST/BLAT: |
OTTHUMG00000018966 |
| Locus Specific Databases: |
LRG_521 |