| Long name: |
Biotin Conjugated, Lubricin/SZP Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Lubricin/SZP |
| Specificity: |
This is a highly specific antibody against Lubricin/SZP |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human Lubricin/SZP |
| Gene ID number: |
6401 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
CACP is an autosomal recessive disorder characterized by joint failure associated with noninflammatory synoviocyte hyperplasia and subinitimal fibrosis of the synovial capsule, Defects in the gene encoding for lubricin can cause Jakobs syndrome, It is a disulfide-linked homodimer (between Cysteine 1146 and Cysteine 1403) that is essential for protein cleavage, Lubricin inhibits synovial cell adhesion to the cartilage surface, Lubricin is highly expressed in cartilage, Lubricin undergoes different levels of glycosylation and may be detected at varying molecular weights, also designated camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP), also designated proteoglycan-4 or megakaryocyte stimulating factor, but also prevents the deposition of proteins from synovial fluid onto cartilage, is important for boundary lubrication within articulating joints, liver and synovial tissue, Lubricin |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
JCAP SZP MSF HAPO bG174L6, 2 FLJ32635 |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Lubricin/SZP Conjugated |
| Short name: |
Conjugated, Lubricin/SZP Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, Lubricin/SZP (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9364 |
| Gene: |
PRG4 |
More about : PRG4 |
| Long gene name: |
proteoglycan 4 |
| Synonyms gene: |
CACP |
| Synonyms gene name: |
(megakaryocyte stimulating factor, arthropathy, articular superficial zone protein, camptodactyly, coxa vara, pericarditis syndrome) , proteoglycan 4 |
| Synonyms name: |
arthropathy, coxa vara, lubricin megakaryocyte stimulating factor articular superficial zone protein Jacobs camptodactyly-arthropathy-pericarditis syndrome camptodactyly, pericarditis syndrome bG174L6, 2 (MSF: megakaryocyte stimulating factor ) |
| Locus: |
1q31, 1 |
| Discovery year: |
2000-07-31 |
| GenBank acession: |
U70136 |
| Entrez gene record: |
10216 |
| Pubmed identfication: |
10545950 9920774 |
| RefSeq identity: |
NM_005807 |
| Havana BLAST/BLAT: |
OTTHUMG00000035574 |