| Long name: |
HAS3 Primary Polyclonal Antibody |
| Also known as: |
HAS3 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
HAS3 |
| Specificity: |
This is a highly specific antibody against HAS3 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HAS3 |
| Gene ID number: |
3038 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Both HAS1 and HAS2 synthesize high molecular-weight HA, HAS2 and HAS3 are HA (hyaluronan or hyaluronic acid) synthase proteins, HAS3 gene expression plays a crucial role in the regulation of hyaluronan synthesis in the epidermis, HAS3 produces both secreted and cell-associated forms of hyaluronan and is the most active of the three isoforms of this enzyme in adults, IFN-g markedly upregulates HAS3 mRNA, Specifically, The expression of the three HAS isoforms is more prominent in growing cells than in resting cells and is differentially regulated by various stimuli, The extracellular matrix in most vertebrates express HA, The human HAS3 gene maps to chromosome 16q22, The three HAS genes show distinct patterns of expression during development and their protein products play significantly different roles in the formation of the HA matrix, suggesting distinct functional roles of the three proteins, whereas HAS3 produces lower molecular weight HA, whereas TGF Beta downregulates HAS3 transcript levels, which is a high molecular weight linear polysaccharide composed of alternating glucuronic acid and N-acetylglucosamine residues linked by b-1, 1, 3 and b-1, 4 glycosidic bonds, HAS1 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
HAS 3, HAS-3, HAS3, HAS3_HUMAN, Hyaluronan synthase 3, Hyaluronate synthase 3, Hyaluronic acid synthase 3, HA synthase 3 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
HAS3 |
| Short name: |
HAS3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
HAS3 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
4820 |
| Gene: |
HAS3 |
More about : HAS3 |
| Long gene name: |
hyaluronan synthase 3 |
| Locus: |
16q22, 1 |
| Discovery year: |
1996-10-18 |
| GenBank acession: |
BC021853 |
| Entrez gene record: |
3038 |
| Pubmed identfication: |
9169154 9083017 |
| RefSeq identity: |
NM_138612 |
| Classification: |
Glycosyltransferase family 2 |
| Havana BLAST/BLAT: |
OTTHUMG00000137562 |