| Long name: |
ALEXA FLUOR 647 Conjugated, Gigaxonin Polyclonal Antibody |
| Also known as: |
Anti-Gigaxonin PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Gigaxonin |
| Specificity: |
This is a highly specific antibody against Gigaxonin |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Gigaxonin |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
GAN1, Gigaxonin is a member of the cytoskeletal BTB/kelch repeat family and influences cytoskeletal organization and dynamics, Mutations in the Gigaxonin gene result in human giant axonal neuropathy (GAN), Overexpression of MAP1B may lead to neuronal cell death, The amino terminal BTB domain of gigaxonin binds to the ubiquitin-activating enzyme E1, also refered to as giant axonal neuropathy, an autosomal recessive neurodegenerative disorder characterized by axonal degeneration caused by cytoskeletal abnormalities, and tags it for degredation, controls protein degradation and is essential for neuronal function and survival, including accumulated intermediate filaments, or KLHL16, playing a large role in neurofilament architecture, whereas a reduction of MAP1B significantly improves the survival rate of neurons, while the carboxy-terminal kelch repeat domain interacts directly with the light chain of microtubule-associated protein 1B (MAP1B), Gigaxonin |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
GAN1 KLHL16 |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the Gigaxonin Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
Gigaxonin |
| Short name: |
Gigaxonin Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, Gigaxonin (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
4137 |
| Gene: |
GAN |
More about : GAN |
| Long gene name: |
gigaxonin |
| Synonyms gene name: |
giant axonal neuropathy (gigaxonin) |
| Synonyms name: |
kelch-like family member 16 |
| Locus: |
16q23, 2 |
| Discovery year: |
1998-09-14 |
| GenBank acession: |
AF291673 |
| Entrez gene record: |
8139 |
| Pubmed identfication: |
9450783 11062483 |
| Classification: |
BTB domain containing Kelch like |
| Havana BLAST/BLAT: |
OTTHUMG00000137627 |
| Locus Specific Databases: |
Inherited Peripheral Neuropathies Mutation Database LRG_242 |