Gigaxonin Antibody

Catalog number:	bs-11025R Buy Now
Price:	729 €
Supplier:	genways
Product name:	Gigaxonin Antibody
Quantity:	1 tube
Related search:	gigaxonin antibody gan gene axonal kelch synonyms storage

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Long name:	Gigaxonin Primary Polyclonal Antibody
Also known as:	Gigaxonin PAb
Category:	Primary Antibodies
Conjugation:	Unconjugated
Target Antigen:	Gigaxonin
Specificity:	This is a highly specific antibody against Gigaxonin
Modification(s):	None
Modification site(s):	Unmodified antibody
Clonality:	Polyclonal antibody
Clone number:	Polyclonal antibody
Concentration:	1ug per 1ul
Source:	This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Gigaxonin
Tested Applications:	IF(IHC-P), IHC-P
Recommended dilutions:	IF(IHC-P)(1:50-200), IHC-P(1:100-500)
Cross reactivity:	Mouse, Rat, Human
Cross reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen:	GAN1, Gigaxonin is a member of the cytoskeletal BTB/kelch repeat family and influences cytoskeletal organization and dynamics, Mutations in the Gigaxonin gene result in human giant axonal neuropathy (GAN), Overexpression of MAP1B may lead to neuronal cell death, The amino terminal BTB domain of gigaxonin binds to the ubiquitin-activating enzyme E1, also refered to as giant axonal neuropathy, an autosomal recessive neurodegenerative disorder characterized by axonal degeneration caused by cytoskeletal abnormalities, and tags it for degredation, controls protein degradation and is essential for neuronal function and survival, including accumulated intermediate filaments, or KLHL16, playing a large role in neurofilament architecture, whereas a reduction of MAP1B significantly improves the survival rate of neurons, while the carboxy-terminal kelch repeat domain interacts directly with the light chain of microtubule-associated protein 1B (MAP1B), Gigaxonin
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names:	GAN, GAN1, GAN_HUMAN, KLHL16, Kelch-like protein 16, giant axonal neuropathy, FLJ38059
Properties:	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene target:	Gigaxonin
Short name:	Gigaxonin Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Alternative name:	Gigaxonin (Antibody to)
Alternative technique:	antibodies
Identity:	4137
Gene:	GAN | More about : GAN
Long gene name:	gigaxonin
Synonyms gene name:	giant axonal neuropathy (gigaxonin)
Synonyms:	GAN1 KLHL16
Synonyms name:	kelch-like family member 16
Locus:	16q23, 2
Discovery year:	1998-09-14
GenBank acession:	AF291673
Entrez gene record:	8139
Pubmed identfication:	9450783 11062483
Classification:	BTB domain containing Kelch like
Havana BLAST/BLAT:	OTTHUMG00000137627
Locus Specific Databases:	Inherited Peripheral Neuropathies Mutation Database LRG_242

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