| Long name: |
FITC Conjugated, VAV3(Tyr141) Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
VAV3 Tyr141 |
| Specificity: |
This is a highly specific antibody against VAV3 Tyr141 |
| Modification: |
Phosphorylation |
| Modification site: |
Tyr141 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human VAV3 around the phosphorylation site of Tyr141 |
| Gene ID number: |
10451 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Encforced Vav3 expression leads to the appearance of multinucleate cells, Following these events, Furthermore, SLP76 and 3BP2, Vav affects IL-2 promotor activity, Vav3, Vav3 expression follows a cell cycle-dependent pattern, and subsequently interacts with 2 adaptor molecules, however, implicating a role for Vav3 in the control of cytokinesis, like Vav (also known as Vav1 or p95Vav), the paths of Vav and Vav3 diverge, undergoes tyrosine phosphorylation downstream of T cell receptor cross-linkage, while Vav3 impacts gene transcription linked to serum response element (SRE), with transient upregulation occuring during mitosis, The Vav family of Rho guanine nucleotide exchange factors (GEFs) orchestrate signaling events following lymphocyte antigen receptor activation |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
VAV3(Tyr141) Conjugated |
| Short name: |
FITC Conjugated, VAV3(Tyr141) Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, vav 3 guanine nucleotide exchange factor(Tyr141) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Plasma membranes, VAV3 and IDBG-100649 and ENSG00000134215 and 10451, VAV3 and IDBG-635847 and ENSBTAG00000031575 and 521961, Vav3 and IDBG-188386 and ENSMUSG00000033721 and 57257, metal ion binding, this GO :0001525 and angiogenesis and biological process this GO :0005070 and SH3/SH2 adaptor activity and molecular function this GO :0005085 and guanyl-nucleotide exchange factor activity and molecular function this GO :0005089 and Rho guanyl-nucleotide exchange factor activity and molecular function this GO :0005096 and GTPase activator activity and molecular function this GO :0005154 and epidermal growth factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006906 and vesicle fusion and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0007229 and integrin-mediated signaling pathway and biological process this GO :0007264 and small GTPase mediated signal transduction and biological process this GO :0007596 and blood coagulation and biological process this GO :0009967 and positive regulation of signal transduction and biological process this GO :0016477 and cell migration and biological process this GO :0030031 and cell projection assembly and biological process this GO :0030032 and lamellipodium assembly and biological process this GO :0030168 and platelet activation and biological process this GO :0030593 and neutrophil chemotaxis and biological process this GO :0030676 and Rac guanyl-nucleotide exchange factor activity and molecular function this GO :0030890 and positive regulation of B cell proliferation and biological process this GO :0032314 and regulation of Rac GTPase activity and biological process this GO :0032319 and regulation of Rho GTPase activity and biological process this GO :0032321 and positive regulation of Rho GTPase activity and biological process this GO :0035023 and regulation of Rho protein signal transduction and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0038096 and Fc-gamma receptor signaling pathway involved in pha this GO cytosis and biological process this GO :0042493 and response to drug and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043087 and regulation of GTPase activity and biological process this GO :0043547 and positive regulation of GTPase activity and biological process this GO :0043552 and positive regulation of phosphatidylinositol 3-kinase activity and biological process this GO :0045087 and innate immune response and biological process this GO :0045785 and positive regulation of cell adhesion and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0050853 and B cell receptor signaling pathway and biological process this GO :0051056 and regulation of small GTPase mediated signal transduction and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0097190 and apoptotic signaling pathway and biological process, this GO :0005070 : SH3/SH2 adaptor activity, this GO :0005070 : SH3/SH2 adaptor activity and also this GO :0005085 : guanyl-nucleotide exchange factor activity and also this GO :0005089 : Rho guanyl-nucleotide exchange factor activity and also this GO :0005096 : GTPase activator activity and also this GO :0005154 : epidermal growth factor receptor binding and also this GO :0005515 : protein binding and also this GO :0030676 : Rac guanyl-nucleotide exchange factor activity and also this GO :0046872 : metal ion binding, this GO :0005085 : guanyl-nucleotide exchange factor activity, this GO :0005089 : Rho guanyl-nucleotide exchange factor activity, this GO :0005096 : GTPase activator activity, this GO :0005154 : epidermal growth factor receptor binding, this GO :0005515 : protein binding, this GO :0030676 : Rac guanyl-nucleotide exchange factor activity, this GO :0046872 : metal ion binding, vav 3 guanine nucleotide exchange factor |
| Identity: |
12659 |
| Gene: |
VAV3 |
More about : VAV3 |
| Long gene name: |
vav guanine nucleotide exchange factor 3 |
| Synonyms gene name: |
vav 3 oncogene vav 3 guanine nucleotide exchange factor |
| Locus: |
1p13, 3 |
| Discovery year: |
1999-07-07 |
| GenBank acession: |
AF118886 |
| Entrez gene record: |
10451 |
| RefSeq identity: |
NM_006113 |
| Classification: |
Rho guanine nucleotide exchange factors Pleckstrin homology domain containing SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000010995 |