| Long name: |
TrkA Primary Polyclonal Antibody |
| Also known as: |
TrkA PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
TrkA |
| Specificity: |
This is a highly specific antibody against TrkA |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TrkA |
| Gene ID number: |
4914 |
| Tested Applications: |
FCM, IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
FCM(1:20-100), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
BDNF and to a lesser extent, By comparison, NGFR p175, NGFR p175 accelerates Trk activation and may recruit downstream dffector molecules to the ligand-bound receptor complex, NT-3, Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk gp 140 in neural cell lines and in embryonic dorsal root ganglia, The prototype member of this gene family, The third member of the Trk receptor family, Trk A, Trk C gp140, Trk C incodes a 140 kDa protein, binds to neurotrophic factors with low affinity but is required for efficient signaling, but not NGF, can induce tyrosine phophorylayion of Trk B gp 145, encodes a 140 kDa cell surface receptor , gp140, that is preferentially expressed in brain tissue and primarily functions as a receptor for NT-3, the expression of which is restricted in vivo to neurons of the sensory spinal and cranial gangliaof neurocrest origin, An additional component of the Trk receptor complex, The Trk family of nerve growth factor receptors includes Trk A(also referfed to as Trk A gp140), Trk B and Trk C |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CIPA, DKFZp781I14186, High affinity nerve growth factor receptor, High affinity nerve growth factor receptor precursor, High affinity nerve growth factor receptor precursor, MTC, MTC, NTRK1_HUMAN, Ntrk 1, Ntrk1, Ntrk1, Oncogene TRK, Oncogene TRK, TRK, TRK, TRK 1, TRK1, TRK1 transforming tyrosine kinase protein, TRK1-transforming tyrosine kinase protein, Trk A, Trk-A, Tropomyosin-related kinase A, Tyrosine Receptor Kinase A, Tyrosine kinase receptor, Tyrosine kinase receptor A, gp140trk, neurotrophic tyrosine kinase receptor type 1, neurotrophic tyrosine kinase receptor type 1, p140 TrkA, p140-TrkA, CIPA |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
TrkA |
| Short name: |
TrkA Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TrkA (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8031 |
| Gene: |
NTRK1 |
More about : NTRK1 |
| Long gene name: |
neurotrophic receptor tyrosine kinase 1 |
| Synonyms gene name: |
neurotrophic tyrosine kinase, receptor, type 1 |
| Synonyms: |
TRK TRKA MTC |
| Synonyms name: |
high affinity nerve growth factor receptor |
| Locus: |
1q23, 1 |
| Discovery year: |
1991-07-18 |
| GenBank acession: |
Y09028 |
| Entrez gene record: |
4914 |
| Pubmed identfication: |
2869410 |
| RefSeq identity: |
NM_002529 |
| Classification: |
Immunoglobulin like domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000041304 |
| Locus Specific Databases: |
Inherited Peripheral Neuropathies Mutation Database LRG_261 |