| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
TrkA |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the TrkA antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This TrkA antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P04629 |
| Purity: |
Antigen affinity |
| Description: |
Higher affinity binding of NGFR can achieved by association with higher molecular mass, Indo et al, NTF3 also binds to TRKA and TRKB, NTF4 (Neurotrophin-4) and BDNF, Nerve Growth Factor(NGF), Sp3 is a bifunctional transcription factor that has been reported to stimulate or repress the transcription of numerous genes, TRKA, TRKA(NTRK1), TRKB, TRKB(NTRK2), The absence of tyrosine kinase receptor A expression was associated with a strong increase in the Sp3 repressor short isoform(s) and a lack of the Sp3 activator long isoform, These results also implicate genes encoding other TRK and neurotrophin family members as candidates for developmental defect(s) of the nervous system, and NTF3 (Neurotrophin-3), and TRKC are specific for or preferred by NGF, and TRKC(NTRK3), but with significantly lower affinity, low-affinity neurotrophin receptors, namely the tropomyosin receptor kinases, respectively, (1996) concluded that defects in TRKA cause CIPA(Congenital insensitivity to pain with anhidrosis) and that the NGF-TRKA system has a crucial role in the development and function of the nociceptive reception as well as establishment of thermoregulation via sweating in humans, Neurotrophic tyrosine kinase receptor A is the high affinity catalytic receptor for the neurotrophin |
| Immunogen: |
Amino acids 342-361 (RHGCLRLNQPTHVNNGNYTL-human) were used as the immunogen for this TrkA antibodyA synthetic peptide corresponding to a |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the TrkA antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
TrkA |
| Short name: |
TrkA Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TrkA (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8031 |
| Gene: |
NTRK1 |
More about : NTRK1 |
| Long gene name: |
neurotrophic receptor tyrosine kinase 1 |
| Synonyms gene name: |
neurotrophic tyrosine kinase, receptor, type 1 |
| Synonyms: |
TRK TRKA MTC |
| Synonyms name: |
high affinity nerve growth factor receptor |
| Locus: |
1q23, 1 |
| Discovery year: |
1991-07-18 |
| GenBank acession: |
Y09028 |
| Entrez gene record: |
4914 |
| Pubmed identfication: |
2869410 |
| RefSeq identity: |
NM_002529 |
| Classification: |
Immunoglobulin like domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000041304 |
| Locus Specific Databases: |
Inherited Peripheral Neuropathies Mutation Database LRG_261 |