| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
TrkA |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, FACS, WB |
| Recommended dilutions: |
Flow Cytometry: 1:10-1:50, Western blot: 1:1000 |
| Notes: |
Titration of the TrkA antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This TrkA antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P04629 |
| Purity: |
Antigen affinity |
| Description: |
Alternate transcriptional splice variants of this gene have been found, Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation, Isoform 3 is resistant to NGF, Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed, Its presence leads to cell differentiation and may play a role in specifying sensory neuron subtypes, This kinase is a membrane-bound receptor that, [Isoform 3 information courtesy of UniProt], but only three have been characterized to date, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade, phosphorylates itself and members of the MAPK pathway, upon neurotrophin binding, This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family |
| Immunogen: |
A portion of amino acids 654-683 from the human protein was used as the immunogen for this TrkA antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot the TrkA antibody and store frozen at -20 deg, Store at 4oC for up to one month |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
TrkA |
| Short name: |
TrkA Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TrkA (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8031 |
| Gene: |
NTRK1 |
More about : NTRK1 |
| Long gene name: |
neurotrophic receptor tyrosine kinase 1 |
| Synonyms gene name: |
neurotrophic tyrosine kinase, receptor, type 1 |
| Synonyms: |
TRK TRKA MTC |
| Synonyms name: |
high affinity nerve growth factor receptor |
| Locus: |
1q23, 1 |
| Discovery year: |
1991-07-18 |
| GenBank acession: |
Y09028 |
| Entrez gene record: |
4914 |
| Pubmed identfication: |
2869410 |
| RefSeq identity: |
NM_002529 |
| Classification: |
Immunoglobulin like domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000041304 |
| Locus Specific Databases: |
Inherited Peripheral Neuropathies Mutation Database LRG_261 |