HPV16 E6 protein Antibody, Biotin Conjugated

Catalog number:	bs-0990R-Biotin Buy Now
Price:	333 €
Supplier:	adi
Product name:	HPV16 E6 protein Antibody, Biotin Conjugated
Quantity:	100 μL
Related search:	protein antibody antibodies biotin human cell papillomavirus

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Long name:	Biotin Conjugated, HPV16 E6 protein Polyclonal Antibody
Category:	Conjugated Primary Antibodies
Conjugation:	Biotinylated
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	HPV16 E6 protein
Specificity:	This is a highly specific antibody against HPV16 E6 protein
Modification:	Unmodified
Modification site:	None
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen_range:	100-150/158
Subcellular location:	Nucleus
Source:	synthetic peptide from HPV16-E6 conjugated to KLH
Gene ID number:	1489078
Swiss Prot:	P03126
Tested applications:	IHC-P
Recommended dilutions:	IHC-P(1:100-500)
Crossreactivity:	Virus
Crossreactive species details:	HPV16
Antigen background:	Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development, E6 also inhibits immune response by interacting with host IRF3 and TYK2, E6 associates with host E6-AP ubiquitin-protein ligase, Fas-associated death domain-containing protein (FADD) and procaspase 8, In turn, Other cellular targets including Bak, The complex E6/E6P targets several other substrates to degradation via the proteasome including host NFX1-91, The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization, These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway, a repressor of human telomerase reverse transcriptase (hTERT), and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation, are degraded by E6/E6AP causing inhibition of apoptosis, Plays a major role in the induction and maintenance of cellular transformation
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Synonyms:	E6 protein, HPV16 E6, HPV16 E6 protein, HPV16-E6, Human Papilloma Virus, Human papillomavirus type 16, Human papillomavirus type 16 E6, Protein E6, VE6_HPV16, E6
Properties:	Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene target:	HPV16 E6 protein Conjugated
Short name:	Conjugated, HPV16 E6 protein Antibody
Technique:	antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label:	Biotin
Alternative name:	biotinilated coupled, HPV16 E6 protein (Antibody to)
Alternative technique:	antibodies

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