| Long name: |
Livin Primary Polyclonal Antibody |
| Also known as: |
Livin PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Livin |
| Specificity: |
This is a highly specific antibody against Livin |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
100-150/298 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Livin |
| Gene ID number: |
79444 |
| Swiss Prot: |
Q96CA5 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
As it is a weak caspase inhibitor, CASP7 and CASP9, In vitro, Isoform 1 blocks staurosporine-induced apoptosis, Isoform 2 blocks etoposide-induced apoptosis, Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing, Its anti-apoptotic activity is mediated through the inhibition of CASP3, May contribute to caspase inhibition, Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, Suppression of apoptosis is mediated by activation of MAPK8/JNK1, This activation depends on TAB1 and NR2C2/TAK1, and cell cycle control, and possibly also of MAPK9/JNK2, as well as by its E3 ubiquitin-protein ligase activity, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions, cell proliferation, etoposide or staurosporine, inhibits CASP3 and proteolytic activation of pro-CASP9, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival, Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
BIRC7, Baculoviral IAP repeat-containing protein 7, Kidney inhibitor of apoptosis protein, LIVIN, ML-IAP, MLIAP, Melanoma inhibitor of apoptosis protein, RING finger protein 50, RNF50, UNQ5800/PRO19607/PRO21344, KIAP |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Livin |
| Short name: |
Livin Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Livin (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
13702 |
| Gene: |
BIRC7 |
More about : BIRC7 |
| Long gene name: |
baculoviral IAP repeat containing 7 |
| Synonyms gene name: |
baculoviral IAP repeat-containing 7 |
| Synonyms: |
mliap ML-IAP KIAP RNF50 |
| Synonyms name: |
melanoma inhibitor of apoptosis protein kidney inhibitor of apoptosis protein livin inhibitor-of-apoptosis livin |
| Locus: |
20q13, 33 |
| Discovery year: |
2001-03-06 |
| GenBank acession: |
AF301009 |
| Entrez gene record: |
79444 |
| Pubmed identfication: |
11024045 11162435 |
| RefSeq identity: |
NM_139317 |
| Classification: |
Baculoviral IAP repeat containing Ring finger proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000032957 |