| Long name: |
HRP Conjugated, FGFR4/CD334 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
HRP Conjugated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
FGFR4/CD334 |
| Specificity: |
This is a highly specific antibody against FGFR4/CD334 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
40-90/762 |
| Subcellular location: |
Extracellular |
| Source: |
KLH conjugated synthetic peptide derived from human FGFR4 |
| Gene ID number: |
2264 |
| Swiss Prot: |
P22455 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1, FGFR4 signaling is down-regulated by receptor internalization and degradation, GAB1, Ligand binding leads to the activation of several signaling cascades, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, MMP14 promotes internalization and degradation of FGFR4, Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling, PIK3R1 and SOS1, Phosphorylates PLCG1 and FRS2, Phosphorylation of FRS2 triggers recruitment of GRB2, Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation, Required for normal down-regulation of the expression of CYP7A1, and in regulation of lipid metabolism, and mediates activation of RAS, as well as of the AKT1 signaling pathway, bile acid biosynthesis, differentiation and migration, glucose uptake, in response to FGF19, the rate-limiting enzyme in bile acid synthesis, vitamin D metabolism and phosphate homeostasis, 4, 5-trisphosphate, Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% Gentamicin, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
JTK2 CD334 |
| Properties: |
Also monoclonal HRP conjugates are often used for Western Blot, HRP conjugates are often primary rabbit polyclonal antibodies couples to the , found in the roots of , (HRP), C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°, enzyme , horseradish, horseradish peroxidase |
| Gene target: |
FGFR4/CD334 Conjugated |
| Short name: |
Conjugated, FGFR4/CD334 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
HRP |
| Alternative name: |
horseradish peroxidase coupled, FGFR4/CD334 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
3691 |
| Gene: |
FGFR4 |
More about : FGFR4 |
| Long gene name: |
fibroblast growth factor receptor 4 |
| Locus: |
5q35, 2 |
| Discovery year: |
1991-07-25 |
| GenBank acession: |
AF202063 |
| Entrez gene record: |
2264 |
| Classification: |
I-set domain containing CD molecules Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000151523 |