| Long name: |
ALEXA FLUOR 488 Conjugated, FGFR4/CD334 Polyclonal Antibody |
| Also known as: |
Anti-FGFR4/CD334 PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
FGFR4/CD334 |
| Specificity: |
This is a highly specific antibody against FGFR4/CD334 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
40-90/762 |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FGFR4 |
| Gene ID Number: |
2264 |
| Swiss Prot: |
P22455 |
| Tested applications: |
IF(IHC-P), FCM |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1, FGFR4 signaling is down-regulated by receptor internalization and degradation, GAB1, Ligand binding leads to the activation of several signaling cascades, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, MMP14 promotes internalization and degradation of FGFR4, Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling, PIK3R1 and SOS1, Phosphorylates PLCG1 and FRS2, Phosphorylation of FRS2 triggers recruitment of GRB2, Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation, Required for normal down-regulation of the expression of CYP7A1, and in regulation of lipid metabolism, and mediates activation of RAS, as well as of the AKT1 signaling pathway, bile acid biosynthesis, differentiation and migration, glucose uptake, in response to FGF19, the rate-limiting enzyme in bile acid synthesis, vitamin D metabolism and phosphate homeostasis, 4, 5-trisphosphate, Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
JTK2 CD334 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the FGFR4/CD334 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
FGFR4/CD334 |
| Short name: |
FGFR4/CD334 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, FGFR4/CD334 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
3691 |
| Gene: |
FGFR4 |
More about : FGFR4 |
| Long gene name: |
fibroblast growth factor receptor 4 |
| Locus: |
5q35, 2 |
| Discovery year: |
1991-07-25 |
| GenBank acession: |
AF202063 |
| Entrez gene record: |
2264 |
| Classification: |
I-set domain containing CD molecules Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000151523 |