| Long name: |
Biotin Conjugated, CD272 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
CD272 |
| Specificity: |
This is a highly specific antibody against CD272 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
239-289/289 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human B and T-lymphocyte attenuator |
| Gene ID number: |
151888 |
| Swiss Prot: |
Q7Z6A9 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
B7x, BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1), BTLA is not expressed by naive T cells, BTLA-deficient T cells show increased proliferation, Crosslinking BTLA with antigen receptors induces its tyrosine phosphorylation and association with the Src homology domain 2 (SH2)-containing protein tyrosine phosphatases SHP-1 and SHP-2, Thus, a peripheral homolog of B7, an immunoglobulin domain-containing glycoprotein with two immunoreceptor tyrosine-based inhibitory motifs, and BTLA-deficient mice have increased specific antibody responses and enhanced sensitivity to experimental autoimmune encephalomyelitis, and attenuates production of interleukin 2 (IL-2), but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells, is a ligand of BTLA, B and T lymphocyte attenuator (BTLA) |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
BTLA1 CD272 |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
CD272 Conjugated |
| Short name: |
Conjugated, CD272 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, CD272 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
21087 |
| Gene: |
BTLA |
More about : BTLA |
| Long gene name: |
B and T lymphocyte associated |
| Locus: |
3q13, 2 |
| Discovery year: |
2003-08-20 |
| GenBank acession: |
AY293286 |
| Entrez gene record: |
151888 |
| Pubmed identfication: |
12796776 |
| RefSeq identity: |
NM_181780 |
| Classification: |
Immunoglobulin like domain containing CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000159255 |