| Long name: |
ALEXA FLUOR 488 Conjugated, Survivin Polyclonal Antibody |
| Also known as: |
Anti-Survivin PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Survivin |
| Specificity: |
This is a highly specific antibody against Survivin |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
93-142/142 |
| Subcellular location: |
Helical |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Survivin |
| Gene ID Number: |
332 |
| Swiss Prot: |
O15392 |
| Tested applications: |
IF(IHC-P), FCM |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Acts as an important regulator of the localization of this complex, Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis, Inhibitor of CASP3 and CASP7, Isoform 2 and isoform 3 do not appear to play vital roles in mitosis, Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform, May counteract a default induction of apoptosis in G2/M phase, May play a role in neoplasia, The acetylated form represses STAT3 transactivation of target gene promoters, The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules, directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules, Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
EPR-1 survivin |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the Survivin Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
Survivin |
| Short name: |
Survivin Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, Survivin (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
593 |
| Gene: |
BIRC5 |
More about : BIRC5 |
| Long gene name: |
baculoviral IAP repeat containing 5 |
| Synonyms gene: |
API4 |
| Synonyms gene name: |
apoptosis inhibitor 4 baculoviral IAP repeat-containing 5 |
| Synonyms name: |
survivin variant 3 alpha |
| Locus: |
17q25, 3 |
| Discovery year: |
1998-06-10 |
| GenBank acession: |
U75285 |
| Entrez gene record: |
332 |
| Pubmed identfication: |
8106347 7947793 |
| RefSeq identity: |
NM_001168 |
| Classification: |
Baculoviral IAP repeat containing Chromosomal passenger complex |
| Havana BLAST/BLAT: |
OTTHUMG00000177505 |