| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Survivin |
| Specificity: |
This antibody reacts specifically with Survivin |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Survivin |
| Gene ID: |
332 |
| Swiss Prot: |
O15392 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Acts as an important regulator of the localization of this complex, Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis, Inhibitor of CASP3 and CASP7, Isoform 2 and isoform 3 do not appear to play vital roles in mitosis, Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform, May counteract a default induction of apoptosis in G2/M phase, May play a role in neoplasia, The acetylated form represses STAT3 transactivation of target gene promoters, The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules, directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules, Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
EPR-1 survivin |
| Also known as: |
Survivin Polyclonal Antibody |
| Other name: |
Anti-Survivin Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Survivin |
| Short name: |
Anti-Survivin (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Survivin (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
593 |
| Gene: |
BIRC5 |
More about : BIRC5 |
| Long gene name: |
baculoviral IAP repeat containing 5 |
| Synonyms gene: |
API4 |
| Synonyms gene name: |
apoptosis inhibitor 4 baculoviral IAP repeat-containing 5 |
| Synonyms name: |
survivin variant 3 alpha |
| Locus: |
17q25, 3 |
| Discovery year: |
1998-06-10 |
| GenBank acession: |
U75285 |
| Entrez gene record: |
332 |
| Pubmed identfication: |
8106347 7947793 |
| RefSeq identity: |
NM_001168 |
| Classification: |
Baculoviral IAP repeat containing Chromosomal passenger complex |
| Havana BLAST/BLAT: |
OTTHUMG00000177505 |