| Long name: |
Recombinant Human HIF1a/HIF1A Protein |
| Type: |
Recombinant protein |
| Knowledgebase of uniprot: |
1), Gln 717-Asn 826 (NP_001521 |
| Gene name synonym: |
HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 |
| Purification: |
Greater than 95% (SDS-PAGE analysis) |
| Examined analyses: |
ELISA, Western blotting |
| Expressed in: |
Escherichia coli |
| KiloDaltons of the protein: |
1 kDa, 13 |
| Storage conditions: |
For long termstorage, The cycles of freezing and thawing are not recommended as such cycles can damage the structure of the polypeptide chains, freeze and keep at -20°, please, C, C for up to one month, Human HIF1a/HIF1A Protein can be refrigerated at +4° |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, Homo sapiens sapiens), Human proteins, humans , ssp |
| Gene target: |
HIF1a/HIF1A Protein |
| Short name: |
HIF1a/HIF1A Protein |
| Species: |
Humans, Human |
| Alternative name: |
a subunit (basic helix-loop-helix transcription factor)/HIF1A Protein, sapiens hypoxia inducible factor 1, H |
| Alternative to gene target: |
DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006879 and cellular iron ion homeostasis and biological process this GO :0007165 and signal transduction and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0007595 and lactation and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008542 and visual learning and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0010573 and vascular endothelial growth factor production and biological process this GO :0010575 and positive regulation vascular endothelial growth factor production and biological process this GO :0010634 and positive regulation of epithelial cell migration and biological process this GO :0010870 and positive regulation of receptor biosynthetic process and biological process this GO :0014850 and response to muscle activity and biological process this GO :0019896 and axon transport of mitochondrion and biological process this GO :0019899 and enzyme binding and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0021502 and neural fold elevation formation and biological process this GO :0021987 and cerebral cortex development and biological process this GO :0030154 and cell differentiation and biological process this GO :0030502 and negative regulation of bone mineralization and biological process this GO :0030949 and positive regulation of vascular endothelial growth factor receptor signaling pathway and biological process this GO :0031514 and motile cilium and cellular component this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0032007 and negative regulation of TOR signaling and biological process this GO :0032364 and oxygen homeostasis and biological process this GO :0032722 and positive regulation of chemokine production and biological process this GO :0032909 and regulation of transforming growth factor beta2 production and biological process this GO :0032963 and collagen metabolic process and biological process this GO :0035035 and histone acetyltransferase binding and molecular function this GO :0035162 and embryonic hemopoiesis and biological process this GO :0035257 and nuclear hormone receptor binding and molecular function this GO :0035774 and positive regulation of insulin secretion involved in cellular response to glucose stimulus and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042541 and hemoglobin biosynthetic process and biological process this GO :0042593 and glucose homeostasis and biological process this GO :0042789 and mRNA transcription from RNA polymerase II promoter and biological process this GO :0042826 and histone deacetylase binding and molecular function this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0043619 and regulation of transcription from RNA polymerase II promoter in response to oxidative stress and biological process this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045648 and positive regulation of erythrocyte differentiation and biological process this GO :0045766 and positive regulation of angiogenesis and biological process this GO :0045821 and positive regulation of glycolytic process and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045926 and negative regulation of growth and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046716 and muscle cell cellular homeostasis and biological process this GO :0046886 and positive regulation of hormone biosynthetic process and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0046983 and protein dimerization activity and molecular function this GO :0048514 and blood vessel morphogenesis and biological process this GO :0048546 and digestive tract morphogenesis and biological process this GO :0050790 and regulation of catalytic activity and biological process this GO :0051000 and positive regulation of nitric-oxide synthase activity and biological process this GO :0051216 and cartilage development and biological process this GO :0051541 and elastin metabolic process and biological process this GO :0051879 and Hsp90 protein binding and molecular function this GO :0060574 and intestinal epithelial cell maturation and biological process this GO :0061030 and epithelial cell differentiation involved in mammary gland alveolus development and biological process this GO :0061298 and retina vasculature development in camera-type eye and biological process this GO :0061418 and regulation of transcription from RNA polymerase II promoter in response to hypoxia and biological process this GO :0061419 and positive regulation of transcription from RNA polymerase II promoter in response to hypoxia and biological process this GO :0070101 and positive regulation of chemokine-mediated signaling pathway and biological process this GO :0070243 and regulation of thymocyte apoptotic process and biological process this GO :0070244 and negative regulation of thymocyte apoptotic process and biological process this GO :0071347 and cellular response to interleukin-1 and biological process this GO :0071456 and cellular response to hypoxia and biological process this GO :0071542 and dopaminergic neuron differentiation and biological process this GO :2001054 and negative regulation of mesenchymal cell apoptotic process and biological process, HIF1A and IDBG-646757 and ENSBTAG00000020935 and 281814, HIF1A and IDBG-8510 and ENSG00000100644 and 3091, Hif1a and IDBG-148620 and ENSMUSG00000021109 and 15251, Hsp90 protein binding, alpha subunit (basic helix-loop-helix transcription factor), bHLHe78 and HIF-1A and HIF-1alpha and HIF1 and HIF1-ALPHA and MOP1 and PASD8, nuclei, this GO :0000989 and transcription factor binding transcription factor activity and molecular function this GO :0001076 and RNA polymerase II transcription factor binding transcription factor activity and molecular function this GO :0001077 and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and molecular function this GO :0001525 and angiogenesis and biological process this GO :0001568 and blood vessel development and biological process this GO :0001666 and response to hypoxia and biological process this GO :0001755 and neural crest cell migration and biological process this GO :0001837 and epithelial to mesenchymal transition and biological process this GO :0001892 and embryonic placenta development and biological process this GO :0001922 and B-1 B cell homeostasis and biological process this GO :0001938 and positive regulation of endothelial cell proliferation and biological process this GO :0001944 and vasculature development and biological process this GO :0001947 and heart looping and biological process this GO :0002052 and positive regulation of neuroblast proliferation and biological process this GO :0002248 and connective tissue replacement involved in inflammatory response wound healing and biological process this GO :0003151 and outflow tract morphogenesis and biological process this GO :0003208 and cardiac ventricle morphogenesis and biological process this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0003705 and RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity and molecular function this GO :0004871 and signal transducer activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005667 and transcription factor complex and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006089 and lactate metabolic process and biological process this GO :0006110 and regulation of glycolytic process and biological process this GO :0006351 and transcription, this GO :0000989 : transcription factor binding transcription factor activity, this GO :0000989 : transcription factor binding transcription factor activity and also this GO :0001076 : RNA polymerase II transcription factor binding transcription factor activity and also this GO :0001077 : RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and also this GO :0003677 : DNA binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0003705 : RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity and also this GO :0004871 : signal transducer activity and also this GO :0005515 : protein binding and also this GO :0008134 : transcription factor binding and also this GO :0019899 : enzyme binding and also this GO :0019901 : protein kinase binding and also this GO :0031625 : ubiquitin protein ligase binding and also this GO :0035035 : histone acetyltransferase binding and also this GO :0035257 : nuclear hormone receptor binding and also this GO :0042826 : histone deacetylase binding and also this GO :0043565 : sequence-specific DNA binding and also this GO :0044212 : transcription regulatory region DNA binding and also this GO :0046982 : protein heterodimerization activity and also this GO :0046983 : protein dimerization activity and also this GO :0051879 : Hsp90 protein binding, this GO :0001076 : RNA polymerase II transcription factor binding transcription factor activity, this GO :0001077 : RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription, this GO :0003677 : DNA binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0003705 : RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity, this GO :0004871 : signal transducer activity, this GO :0005515 : protein binding, this GO :0008134 : transcription factor binding, this GO :0019899 : enzyme binding, this GO :0019901 : protein kinase binding, this GO :0031625 : ubiquitin protein ligase binding, this GO :0035035 : histone acetyltransferase binding, this GO :0035257 : nuclear hormone receptor binding, this GO :0042826 : histone deacetylase binding, this GO :0043565 : sequence-specific DNA binding, this GO :0044212 : transcription regulatory region DNA binding, this GO :0046982 : protein heterodimerization activity, this GO :0046983 : protein dimerization activity, this GO :0051879 : Hsp90 protein binding, hypoxia inducible factor 1 |
| Identity: |
4910 |
| Gene: |
HIF1A |
More about : HIF1A |
| Long gene name: |
hypoxia inducible factor 1 alpha subunit |
| Synonyms gene name: |
alpha subunit (basic helix-loop-helix transcription factor) , hypoxia inducible factor 1 |
| Synonyms: |
MOP1 HIF-1alpha PASD8 HIF1 bHLHe78 |
| Locus: |
14q23, 2 |
| Discovery year: |
1995-03-27 |
| GenBank acession: |
U22431 |
| Entrez gene record: |
3091 |
| Pubmed identfication: |
8786149 9079689 |
| RefSeq identity: |
NM_001530 |
| Classification: |
Basic helix-loop-helix proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000140344 |