| Long name: |
Cy7 Conjugated, RAR alpha Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Cy7 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
RAR alpha |
| Specificity: |
This is a highly specific antibody against RAR alpha |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
410-462/462 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
OVA conjugated synthetic peptide derived from mouse Retinoic acid Receptor Alpha |
| Gene ID number: |
19401 |
| Swiss Prot: |
P11416 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Has a role in the survival of early spermatocytes at the beginning prophase of meiosis, In Sertoli cells, In concert with RARG, In the absence of ligand, Mediates retinoic acid-induced granulopoiesis, On ligand binding, RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis, Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, chromatin condensation and transcriptional suppression, matrix homeostasis and growth plate function, may promote the survival and development of early meiotic prophase spermatocytes, required for skeletal growth, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation, Receptor for retinoic acid |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
743nm/767nm |
| Synonyms: |
RAR NR1B1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Conjugated: |
These antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths |
| Gene target: |
RAR alpha Conjugated |
| Short name: |
Conjugated, RAR alpha Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Cy7 |
| Alternative name: |
cyanine 7 coupled, RAR a (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9864 |
| Gene: |
RARA |
More about : RARA |
| Long gene name: |
retinoic acid receptor alpha |
| Synonyms gene name: |
alpha , retinoic acid receptor |
| Locus: |
17q21, 2 |
| Discovery year: |
1988-06-09 |
| GenBank acession: |
X06538 |
| Entrez gene record: |
5914 |
| Pubmed identfication: |
2825036 8244378 |
| Classification: |
Nuclear hormone receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000133328 |
| Locus Specific Databases: |
LRG_1070 |