| Long name: |
ALEXA FLUOR 350 Conjugated, RAR alpha Polyclonal Antibody |
| Also known as: |
Anti-RAR alpha PAb ALEXA FLUOR 350 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
350, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
RAR alpha |
| Specificity: |
This is a highly specific antibody against RAR alpha |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
410-462/462 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
OVA conjugated synthetic peptide derived from mouse Retinoic acid Receptor Alpha |
| Gene ID Number: |
19401 |
| Swiss Prot: |
P11416 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Has a role in the survival of early spermatocytes at the beginning prophase of meiosis, In Sertoli cells, In concert with RARG, In the absence of ligand, Mediates retinoic acid-induced granulopoiesis, On ligand binding, RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis, Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5, Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes, chromatin condensation and transcriptional suppression, matrix homeostasis and growth plate function, may promote the survival and development of early meiotic prophase spermatocytes, required for skeletal growth, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation, Receptor for retinoic acid |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
343nm/442nm |
| Synonyms: |
RAR NR1B1 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 350, Alexa Fluor |
| Gene target: |
RAR alpha |
| Short name: |
RAR alpha Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 350 |
| Alternative name: |
ALEXA FLUOR 350, RAR a (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9864 |
| Gene: |
RARA |
More about : RARA |
| Long gene name: |
retinoic acid receptor alpha |
| Synonyms gene name: |
alpha , retinoic acid receptor |
| Locus: |
17q21, 2 |
| Discovery year: |
1988-06-09 |
| GenBank acession: |
X06538 |
| Entrez gene record: |
5914 |
| Pubmed identfication: |
2825036 8244378 |
| Classification: |
Nuclear hormone receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000133328 |
| Locus Specific Databases: |
LRG_1070 |