| Long name: |
ALEXA FLUOR 488 Conjugated, PDGFRA Polyclonal Antibody |
| Also known as: |
Anti-PDGFRA PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
PDGFRA |
| Specificity: |
This is a highly specific antibody against PDGFRA |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
1020-1070/1089 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PDGF-R-A |
| Gene ID Number: |
5156 |
| Swiss Prot: |
P16234 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1, Binding of its cognate ligands - homodimeric PDGFA, Depending on the context, Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, PLCG1, Phosphorylates PIK3R1, Phosphorylates PIK3R1, Plays a role in cell migration and chemotaxis in wound healing, Plays a role in platelet activation, Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells, Promotes activation of STAT family members STAT1, Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, Required for normal development of the mucosa lining the gastrointestinal tract, Required for normal skeleton development and cephalic closure during embryonic development, STAT3 and STAT5A and/or STAT5B, and PTPN11, and by rapid internalization of the activated receptor, and for recruitment of mesenchymal cells and normal development of intestinal villi, and in thrombin-induced platelet aggregation, and thereby mediates activation of the AKT1 signaling pathway, cell proliferation, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades, homodimeric PDGFB, mobilization of cytosolic Ca(2+) and the activation of protein kinase C, promotes or inhibits cell proliferation and cell migration, secretion of agonists from platelet granules, survival and chemotaxis, the regulatory subunit of phosphatidylinositol 3-kinase, the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB, 4, 5-trisphosphate, Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
CD140a PDGFR2 GAS9 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the PDGFRA Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
PDGFRA |
| Short name: |
PDGFRA Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, a polypeptide (Antibody to), platelet-derived growth factor receptor |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CD140A and PDGFR-2 and PDGFR2 and RHEPDGFRA, PDGFRA and IDBG-18854 and ENSG00000134853 and 5156, PDGFRA and IDBG-642308 and ENSBTAG00000007173 and 282301, Pdgfra and IDBG-171929 and ENSMUSG00000029231 and 18595, alpha polypeptide, nuclei, this GO :0001553 and luteinization and biological process this GO :0001701 and in utero embryonic development and biological process this GO :0001775 and cell activation and biological process this GO :0002244 and hematopoietic progenitor cell differentiation and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004714 and transmembrane receptor protein tyrosine kinase activity and molecular function this GO :0005018 and platelet-derived growth factor alpha-receptor activity and molecular function this GO :0005021 and vascular endothelial growth factor-activated receptor activity and molecular function this GO :0005161 and platelet-derived growth factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0005902 and microvillus and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007169 and transmembrane receptor protein tyrosine kinase signaling pathway and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007204 and positive regulation of cytosolic calcium ion concentration and biological process this GO :0008210 and estrogen metabolic process and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0008585 and female this GO nad development and biological process this GO :0009653 and anatomical structure morphogenesis and biological process this GO :0009887 and organ morphogenesis and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0010544 and negative regulation of platelet activation and biological process this GO :0010863 and positive regulation of phospholipase C activity and biological process this GO :0014068 and positive regulation of phosphatidylinositol 3-kinase signaling and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016032 and viral process and biological process this GO :0016477 and cell migration and biological process this GO :0016772 and transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004714 : transmembrane receptor protein tyrosine kinase activity and also this GO :0005018 : platelet-derived growth factor alpha-receptor activity and also this GO :0005021 : vascular endothelial growth factor-activated receptor activity and also this GO :0005161 : platelet-derived growth factor receptor binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004714 : transmembrane receptor protein tyrosine kinase activity, this GO :0005018 : platelet-derived growth factor alpha-receptor activity, this GO :0005021 : vascular endothelial growth factor-activated receptor activity, this GO :0005161 : platelet-derived growth factor receptor binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0038085 : vascular endothelial growth factor binding, this GO :0042803 : protein homodimerization activity, this GO :0048407 : platelet-derived growth factor binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0038085 : vascular endothelial growth factor binding and also this GO :0042803 : protein homodimerization activity and also this GO :0048407 : platelet-derived growth factor binding, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0023019 and signal transduction involved in regulation of gene expression and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0030324 and lung development and biological process this GO :0030325 and adrenal gland development and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0030539 and male genitalia development and biological process this GO :0031226 and intrinsic component of plasma membrane and cellular component this GO :0033327 and Leydig cell differentiation and biological process this GO :0035790 and platelet-derived growth factor receptor-alpha signaling pathway and biological process this GO :0038085 and vascular endothelial growth factor binding and molecular function this GO :0038091 and positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0042060 and wound healing and biological process this GO :0042475 and odontogenesis of dentin-containing tooth and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043552 and positive regulation of phosphatidylinositol 3-kinase activity and biological process this GO :0045087 and innate immune response and biological process this GO :0045740 and positive regulation of DNA replication and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0048008 and platelet-derived growth factor receptor signaling pathway and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0048146 and positive regulation of fibroblast proliferation and biological process this GO :0048407 and platelet-derived growth factor binding and molecular function this GO :0048557 and embryonic digestive tract morphogenesis and biological process this GO :0048701 and embryonic cranial skeleton morphogenesis and biological process this GO :0048704 and embryonic skeletal system morphogenesis and biological process this GO :0048705 and skeletal system morphogenesis and biological process this GO :0050920 and regulation of chemotaxis and biological process this GO :0055003 and cardiac myofibril assembly and biological process this GO :0060021 and palate development and biological process this GO :0060325 and face morphogenesis and biological process this GO :0060326 and cell chemotaxis and biological process this GO :0061298 and retina vasculature development in camera-type eye and biological process this GO :0070374 and positive regulation of ERK1 and ERK2 cascade and biological process this GO :0070527 and platelet aggregation and biological process this GO :0071230 and cellular response to amino acid stimulus and biological process this GO :0072277 and metanephric glomerular capillary formation and biological process this GO :2000249 and regulation of actin cytoskeleton reorganization and biological process this GO :2000739 and regulation of mesenchymal stem cell differentiation and biological process, platelet-derived growth factor receptor |
| Identity: |
8803 |
| Gene: |
PDGFRA |
More about : PDGFRA |
| Long gene name: |
platelet derived growth factor receptor alpha |
| Synonyms gene name: |
alpha polypeptide , platelet-derived growth factor receptor |
| Locus: |
4q12 |
| Discovery year: |
1989-05-19 |
| GenBank acession: |
D50001 |
| Entrez gene record: |
5156 |
| Pubmed identfication: |
8643452 |
| RefSeq identity: |
NM_006206 |
| Classification: |
I-set domain containing CD molecules Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000128699 |
| Locus Specific Databases: |
LRG_309 |