| Long name: |
ALEXA FLUOR 488 Conjugated, VEGFR1 Polyclonal Antibody |
| Also known as: |
Anti-VEGFR1 PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
VEGFR1 |
| Specificity: |
This is a highly specific antibody against VEGFR1 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
1160-1210/1333 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from rat VEGFR1 |
| Gene ID Number: |
54251 |
| Swiss Prot: |
P53767 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1, Can promote endothelial cell proliferation, Has very high affinity for VEGFA and relatively low protein kinase activity, Its function in promoting cell proliferation seems to be cell-type specific, Ligand binding leads to the activation of several signaling cascades, MAPK3/ERK1 and the MAP kinase signaling pathway, May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells, Mediates activation of MAPK1/ERK2, Mediates phosphorylation of PIK3R1, Modulates KDR signaling by forming heterodimers with KDR, Phosphorylates SRC, Promotes PGF-mediated proliferation of endothelial cells, Promotes phosphorylation of AKT1 and PTK2/FAK1 (By similarity), VEGFB and PGF, YES1 and PLCG, and cancer cell invasion, and may also phosphorylate CBL, and plays an essential role in the development of embryonic vasculature, and proliferation of some types of cancer cells, as well as of the AKT1 signaling pathway, but does not promote proliferation of normal fibroblasts, cell migration, cell survival, chemotaxis, leading to the activation of phosphatidylinositol kinase and the downstream signaling pathway, macrophage function, may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR, survival and angiogenesis in adulthood, the regulation of angiogenesis, the regulatory subunit of phosphatidylinositol 3-kinase, 4, 5-trisphosphate and the activation of protein kinase C, Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
VEGFR1 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the VEGFR1 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
VEGFR1 |
| Short name: |
VEGFR1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, VEGFR1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
3763 |
| Gene: |
FLT1 |
More about : FLT1 |
| Long gene name: |
fms related tyrosine kinase 1 |
| Synonyms gene: |
FLT |
| Synonyms gene name: |
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) fms-related tyrosine kinase 1 |
| Synonyms name: |
vascular endothelial growth factor receptor 1 vascular permeability factor receptor |
| Locus: |
13q12, 3 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
AF063657 |
| Entrez gene record: |
2321 |
| Pubmed identfication: |
2158038 |
| RefSeq identity: |
NM_002019 |
| Classification: |
I-set domain containing Immunoglobulin like domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000016648 |
| Locus Specific Databases: |
The Globin Gene Server LRG_425 |