| Long name: |
ALK Primary Polyclonal Antibody |
| Also known as: |
ALK PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
ALK |
| Specificity: |
This is a highly specific antibody against ALK |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CD246 |
| Gene ID number: |
238 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
ALK/ATIC (chromosome 2), ALK/CLTC (chromosome 17), ALK/NPM1 (chromosome 5), ALK/RANBP2 (chromosome 2), ALK/SQSTM1 (chromosome 5), ALK/TFG (chromosome 3), ALK/TPM4 (chromosome 19), It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system, Jan 2011], LK/KIF5B (chromosome 10), The chromosomal rearrangements are the most common genetic alterations in this gene, This gene has been found to be rearranged, This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and ALK/MSN (chromosome X), and an intracellular kinase domain, and non-small cell lung cancer, including ALK (chromosome 2)/EML4 (chromosome 2), mutated, neuroblastoma, or amplified in a series of tumours including anaplastic large cell lymphomas, which belongs to the insulin receptor superfamily, which result in creation of multiple fusion genes in tumourigenesis, This gene encodes a receptor tyrosine kinase, [provided by RefSeq |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
ALK tyrosine kinase receptor precursor, ALK/EML4 fusion gene, ALK/NPM1 fusion gene, Anaplastic lymphoma kinase, Anaplastic lymphoma kinase Ki 1, Anaplastic lymphoma kinase Ki1, Anaplastic lymphoma kinase p80, CD 246, CD-246, CD246, CD246 antigen, EC 2, Ki 1, Ki1, NBLST3, TFG/ALK, Tcrz, anaplastic lymphoma kinase Ki-1, included, included, 1, 7, 10, ALK tyrosine kinase receptor |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
ALK |
| Short name: |
ALK Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
anaplastic lymphoma receptor tyrosine kinase (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ALK and IDBG-42084 and ENSG00000171094 and 238, ALK and IDBG-636042 and ENSBTAG00000007379 and 536642, Alk and IDBG-197259 and ENSMUSG00000055471 and 11682, CD246 and NBLST3, Plasma membranes, this GO :0000187 and activation of MAPK activity and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004704 and NF-kappaB-inducing kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004714 and transmembrane receptor protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007165 and signal transduction and biological process this GO :0007169 and transmembrane receptor protein tyrosine kinase signaling pathway and biological process this GO :0007399 and nervous system development and biological process this GO :0008283 and cell proliferation and biological process this GO :0016020 and membrane and cellular component this GO :0016310 and phosphorylation and biological process this GO :0016772 and transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004704 : NF-kappaB-inducing kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004714 : transmembrane receptor protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004704 : NF-kappaB-inducing kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004714 : transmembrane receptor protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0038061 and NIK/NF-kappaB signaling and biological process this GO :0042981 and regulation of apoptotic process and biological process this GO :0043234 and protein complex and cellular component this GO :0046777 and protein autophosphorylation and biological process this GO :0048666 and neuron development and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, anaplastic lymphoma receptor tyrosine kinase |
| Identity: |
427 |
| Gene: |
ALK |
More about : ALK |
| Long gene name: |
anaplastic lymphoma receptor tyrosine kinase |
| Synonyms gene name: |
anaplastic lymphoma kinase (Ki-1) |
| Synonyms: |
CD246 |
| Locus: |
2p23, 1 , 2-p23 |
| Discovery year: |
1993-08-24 |
| GenBank acession: |
D45915 |
| Entrez gene record: |
238 |
| Pubmed identfication: |
8122112 |
| RefSeq identity: |
NM_004304 |
| Classification: |
CD molecules Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000152034 |
| Locus Specific Databases: |
LRG_488 |