GSK-3 Beta Antibody

Catalog number:	bs-0028M Buy Now
Price:	332 €
Supplier:	Bioss Primary Conjugated Antibodies.
Product name:	GSK-3 Beta Antibody
Quantity:	100ul
Other quantities:	0.1ml 263€
Related search:	antibody beta antibodies glycogen microtubules

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Long name:	GSK-3 Beta Primary Polyclonal Antibody
Also known as:	GSK-3 Beta PAb
Category:	Primary Antibodies
Conjugation:	Unconjugated
Target Antigen:	GSK-3 Beta
Specificity:	This is a highly specific antibody against GSK-3 Beta
Modification(s):	None
Modification site(s):	Unmodified antibody
Clonality:	Polyclonal antibody
Clone number:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen range:	335-380/420
Subcellular location:	Cell membrane, Nucleus, Cytoplasm
Source:	This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human GSK-3 Beta
Gene ID number:	2932
Swiss Prot:	P49841
Tested Applications:	IF(IHC-P), IHC-P, WB
Recommended dilutions:	IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity:	Rat, Human
Cross reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen:	APC, AXIN1, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes, CTNNB1/beta-catenin, DPYSL2/CRMP2, EIF2B, GSK3B forms a multimeric complex with APC, In Wnt signaling, In skeletal muscle, JUN, MAPT/TAU and MACF1, MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease, May also mediate the development of insulin resistance by regulating activation of transcription factors, NFATC1/NFATC, Phosphorylates JUN at sites proximal to its DNA-binding domain, Phosphorylates MACF1, Phosphorylates MAPT/TAU on 'Thr-548', Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex, Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA), Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase, Requires primed phosphorylation of the majority of its substrates, Wnt signaling and regulation of transcription factors and microtubules, and thereby opposing the action of calcineurin, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis, decreasing significantly MAPT/TAU ability to bind and stabilize microtubules, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair, shutting off NFATC1/NFATC gene regulation, thereby reducing its affinity for DNA, Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names:	GSK-3 beta, GSK3B, Serine/threonine-protein kinase GSK3B, Glycogen synthase kinase-3 beta
Properties:	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene target:	GSK-3 Beta
Short name:	GSK-3 Beta Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Alternative name:	GSK-3 b (Antibody to)
Alternative technique:	antibodies

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• #microtubules