GSK-3 Beta Antibody, ALEXA FLUOR 594

Catalog number:	bs-0028M-A594 Buy Now
Price:	350 €
Supplier:	Bioss Primary Conjugated Antibodies.
Product name:	GSK-3 Beta Antibody, ALEXA FLUOR 594
Quantity:	100ul
Other quantities:	100ul 332€
Related search:	alexa beta antibody antibodies glycogen microtubules kinase wnt

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Long name:	ALEXA FLUOR 594 Conjugated, GSK-3 Beta Polyclonal Antibody
Also known as:	Anti-GSK-3 Beta PAb ALEXA FLUOR 594
Category:	Conjugated Primary Antibodies
Conjugated with:	594, ALEXA FLUOR®
Host Organism:	Mouse (Mus musculus)
Target Antigen:	GSK-3 Beta
Specificity:	This is a highly specific antibody against GSK-3 Beta
Modification:	Unmodified
Modification Site:	None
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen range:	335-380/420
Subcellular location:	Cell membrane, Nucleus, Cytoplasm
Source:	This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human GSK-3 Beta
Gene ID Number:	2932
Swiss Prot:	P49841
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Rat, Human
Cross-reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen:	APC, AXIN1, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes, CTNNB1/beta-catenin, DPYSL2/CRMP2, EIF2B, GSK3B forms a multimeric complex with APC, In Wnt signaling, In skeletal muscle, JUN, MAPT/TAU and MACF1, MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease, May also mediate the development of insulin resistance by regulating activation of transcription factors, NFATC1/NFATC, Phosphorylates JUN at sites proximal to its DNA-binding domain, Phosphorylates MACF1, Phosphorylates MAPT/TAU on 'Thr-548', Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex, Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA), Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase, Requires primed phosphorylation of the majority of its substrates, Wnt signaling and regulation of transcription factors and microtubules, and thereby opposing the action of calcineurin, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis, decreasing significantly MAPT/TAU ability to bind and stabilize microtubules, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair, shutting off NFATC1/NFATC gene regulation, thereby reducing its affinity for DNA, Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis
Purification:	Purified by Protein A
Storage conditions:	50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission:	590nm/617nm
Synonyms:	GSK-3 beta, GSK3B, Serine/threonine-protein kinase GSK3B, Glycogen synthase kinase-3 beta
Properties:	ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation:	594, ALEXA FLUOR®, Alexa Fluor
Conjugated:	Alexa conjugate 1
Gene target:	GSK-3 Beta
Short name:	GSK-3 Beta Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Label:	ALEXA FLUOR 594
Alternative name:	ALEXA FLUOR 594, GSK-3 b (Antibody to)
Alternative technique:	antibodies

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