| Reacts with: |
Human |
| Source: |
proteins, Recombinants or rec |
| Description: |
Not all receptor antagonist that bind to enzymes are inhibitors, Since blocking an enzyme's activity can kill a pathogen , activator, caspase, esterase inhibitors , lipoprotein, many drugs are enzyme inhibitors, papain, pathway, peptidase, protease , proteinase, trypsin, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme, , Tissue, acrosin, activity, and decreases its , are , bind to enzymes and increase their , enzymatic activity, enzyme activator ligands or agonists , enzyme receptor , imbalance, metabolic , or correct a , or receptor ligands or receptor antagonists that bind to an , proteins |
| Molecular Weight: |
19, 25 kD |
| UniProt number: |
P38936 |
| State of the product: |
Freeze-dried |
| Shipping conditions: |
Ambient temperature |
| Formulation: |
150 mM sodium chloride, pH 7, 2, 2 um filtered solution of 20 mM PB, Lyophilized from a 0 |
| Storage recommendations: |
-20°, Aliquots of reconstituted samples are stable at less -20°, If kept at at room temperature, If kept at at room temperature, Reconstituted protein solution should be stored at 4-7°, it is stable for 3 weeks, it is stable for 3 weeks, C, C for 2-7 days, C for 3 months, Freeze-dried proteins should be stored frozen at < |
| Reconstitution: |
Dissolve the lyophilized protein in ddH2O, Do not mix by vortex or pipetting, It is not recommended to reconstitute to a concentration less than 100 &mu, Please aliquot the reconstituted solution to minimize freeze-thaw cycles, Always centrifuge tubes before opening, g/ml |
| Purity: |
and determined by Polyacrylamide gel electrophoresis, Greater than 95% |
| Sequence of the amino acid: |
SEPAGDVRQNPCGSKACRRLFGPVDSEQLRRDCDALMAGCIQEARERWNFDFVTETPLEGDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSCTLVPRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFSKRKPLEHHHHHH |
| Levels of endotoxin: |
11 IEU/ug, LAL test shows less than than 0 |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, Homo sapiens sapiens), Human proteins, humans , ssp |
| Group: |
recombinants |
| Gene target: |
CDKN1A, p21 (C-6His), Cyclin-Dependent Kinase Inhibitor 1 |
| Short name: |
CDKN1A, p21 (C-6His), Recombinant Cyclin-Dependent Kinase Inhibitor 1 |
| Technique: |
E, coli recombinant proteins are , novo advises they will be reconstituted in a buffer soluion or culture medium for cell culture, supplied as white sterile powder lyopillized, Recombinant, genetic recombinations , in Escherichia coli |
| Species: |
Humans, Human |
| Alternative name: |
Cip1), cyclin-dependent kinase inhibitor 1A (p21, p21 (C-6His), sapiens Cyclin-Dependent phosphorylation catalyst suppressor 1, recombinant H |
| Alternative technique: |
rec |
| Alternative to gene target: |
CAP20 and CDKN1 and CIP1 and MDA-6 and P21 and p21CIP1 and SDI1 and WAF1, CDKN1A and IDBG-630156 and ENSBTAG00000008353 and 513497, CDKN1A and IDBG-85033 and ENSG00000124762 and 1026, Cdkn1a and IDBG-159848 and ENSMUSG00000023067 and 12575, Cip1), metal ion binding, nuclei, signal transduction by p53 class mediator resulting in cell cycle arrest and biological process this GO :0007050 and cell cycle arrest and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007265 and Ras protein signal transduction and biological process this GO :0007346 and regulation of mitotic cell cycle and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0009411 and response to UV and biological process this GO :0009636 and response to toxic substance and biological process this GO :0010033 and response to organic substance and biological process this GO :0010165 and response to X-ray and biological process this GO :0010243 and response to organonitrogen compound and biological process this GO :0010629 and negative regulation of gene expression and biological process this GO :0014070 and response to organic cyclic compound and biological process this GO :0019912 and cyclin-dependent protein kinase activating kinase activity and molecular function this GO :0030308 and negative regulation of cell growth and biological process this GO :0030332 and cyclin binding and molecular function this GO :0030890 and positive regulation of B cell proliferation and biological process this GO :0031100 and organ regeneration and biological process this GO :0031668 and cellular response to extracellular stimulus and biological process this GO :0032403 and protein complex binding and molecular function this GO :0033158 and regulation of protein import into nucleus, this GO :0000079 and regulation of cyclin-dependent protein serine/threonine kinase activity and biological process this GO :0000082 and G1/S transition of mitotic cell cycle and biological process this GO :0000086 and G2/M transition of mitotic cell cycle and biological process this GO :0000278 and mitotic cell cycle and biological process this GO :0000307 and cyclin-dependent protein kinase holoenzyme complex and cellular component this GO :0004861 and cyclin-dependent protein serine/threonine kinase inhibitor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0006977 and DNA damage response, this GO :0004861 : cyclin-dependent protein serine/threonine kinase inhibitor activity, this GO :0004861 : cyclin-dependent protein serine/threonine kinase inhibitor activity and also this GO :0005515 : protein binding and also this GO :0019912 : cyclin-dependent protein kinase activating kinase activity and also this GO :0030332 : cyclin binding and also this GO :0032403 : protein complex binding and also this GO :0046872 : metal ion binding, this GO :0005515 : protein binding, this GO :0019912 : cyclin-dependent protein kinase activating kinase activity, this GO :0030332 : cyclin binding, this GO :0032403 : protein complex binding, this GO :0046872 : metal ion binding, translocation and biological process this GO :0034605 and cellular response to heat and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0042326 and negative regulation of phosphorylation and biological process this GO :0042493 and response to drug and biological process this GO :0042771 and intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043068 and positive regulation of programmed cell death and biological process this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0045087 and innate immune response and biological process this GO :0045736 and negative regulation of cyclin-dependent protein serine/threonine kinase activity and biological process this GO :0045860 and positive regulation of protein kinase activity and biological process this GO :0046685 and response to arsenic-containing substance and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0048146 and positive regulation of fibroblast proliferation and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0051384 and response to glucocorticoid and biological process this GO :0051412 and response to corticosterone and biological process this GO :0051726 and regulation of cell cycle and biological process this GO :0055093 and response to hyperoxia and biological process this GO :0060574 and intestinal epithelial cell maturation and biological process this GO :0070557 and PCNA-p21 complex and cellular component this GO :0071479 and cellular response to ionizing radiation and biological process this GO :0071850 and mitotic cell cycle arrest and biological process this GO :0071901 and negative regulation of protein serine/threonine kinase activity and biological process this GO :0090398 and cellular senescence and biological process this GO :0090400 and stress-induced premature senescence and biological process this GO :0097193 and intrinsic apoptotic signaling pathway and biological process this GO :2000278 and regulation of DNA biosynthetic process and biological process this GO :2000379 and positive regulation of reactive oxygen species metabolic process and biological process, cyclin-dependent kinase inhibitor 1A (p21 |
| Identity: |
1784 |
| Gene: |
CDKN1A |
More about : CDKN1A |
| Long gene name: |
cyclin dependent kinase inhibitor 1A |
| Synonyms gene: |
CDKN1 |
| Synonyms gene name: |
Cip1) , cyclin-dependent kinase inhibitor 1A (p21 |
| Synonyms: |
P21 CIP1 WAF1 SDI1 CAP20 p21CIP1 p21Cip1/Waf1 |
| Locus: |
6p21, 2 |
| Discovery year: |
1994-05-24 |
| GenBank acession: |
U03106 |
| Entrez gene record: |
1026 |
| RefSeq identity: |
NM_078467 |
| Havana BLAST/BLAT: |
OTTHUMG00000014603 |