| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
SLC5A8 / Sodium-coupled monocarboxylate transporter 1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
Western blot: 1:500-1000 |
| Intented use: |
This SLC5A8 antibodyis to be used only for research purposes and not for diagnostics |
| Gene ID #: |
160728 |
| Uniprot #: |
Q8N695 |
| Purity: |
Antigen affinity |
| Description: |
Acts as a tumor suppressor, Catalyzes passive carrier mediated diffusion of iodide, D-lactate, May be responsible for the absorption of D- lactate and monocarboxylate drugs from the intestinal tract, May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons, Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane, acetate, acetoacetate and alpha-ketoisocaproate), benzoate, including transport of monocarboxylates (short-chain fatty acids including L-lactate, lactate, mocarboxylate drugs (nicotinate, propionate, prostate cancer and glioma cell lines, pyruvate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D- hydroxybutyrate, suppressing colony formation in colon cancer, valerate and butyrate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1, Solute carrier family 5 member 8 acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter |
| Immunogen: |
A portion of amino acids 579-609 from the human protein was used as the immunogen for the SLC5A8 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the SLC5A8 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
SLC5A8 / Sodium-coupled monocarboxylate transporter 1 |
| Short name: |
SLC5A8 Antibody / Sodium-coupled monocarboxylate transporter 1 |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
member 8 (Antibody to) / Sodium-coupled monocarboxylate transporter 1, solute carrier family 5 (iodide transporter) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Plasma membranes, SLC5A8 and IDBG-547244 and ENSG00000256870 and 160728, SMCT1 and IDBG-636931 and ENSBTAG00000011525 and 615734, Slc5a8 and IDBG-183999 and ENSMUSG00000020062 and 216225, member 8, symporter activity, this GO :0005215 and transporter activity and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0006810 and transport and biological process this GO :0006811 and ion transport and biological process this GO :0006814 and sodium ion transport and biological process this GO :0006915 and apoptotic process and biological process this GO :0015293 and symporter activity and molecular function this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016324 and apical plasma membrane and cellular component this GO :0055085 and transmembrane transport and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0005215 : transporter activity, this GO :0005215 : transporter activity and also this GO :0015293 : symporter activity, this GO :0015293 : symporter activity, solute carrier family 5 (iodide transporter) |
| Identity: |
19119 |
| Gene: |
SLC5A8 |
More about : SLC5A8 |
| Long gene name: |
solute carrier family 5 member 8 |
| Synonyms gene name: |
member 8 , member 8 solute carrier family 5 (sodium/monocarboxylate cotransporter), solute carrier family 5 (iodide transporter) |
| Synonyms: |
AIT |
| Locus: |
12q23, 1-q23, 2 |
| Discovery year: |
2003-05-12 |
| GenBank acession: |
AY081220 |
| Entrez gene record: |
160728 |
| Pubmed identfication: |
12107270 12829793 |
| RefSeq identity: |
NM_145913 |
| Classification: |
Solute carriers |
| Havana BLAST/BLAT: |
OTTHUMG00000170499 |