| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
RTN4 / Reticulon 4 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
Western blot: 1:1000-2000 |
| Intented use: |
This RTN4 antibodyis to be used only for research purposes and not for diagnostics |
| Gene ID #: |
57142 |
| Uniprot #: |
Q9NQC3 |
| Purity: |
Antigen affinity |
| Description: |
Involved in down-regulation of growth, Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing, Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2, Regulates neurite fasciculation, Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity), This is likely consecutive to their change in subcellular location, after binding and sequestration, and as a facilitator of neurite branching, branching and extension in the developing nervous system, from the mitochondria to the endoplasmic reticulum, stabilization of wiring and restriction of plasticity in the adult CNS, Reticulon-4 is a developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth |
| Immunogen: |
A portion of amino acids 28-58 from the human protein was used as the immunogen for the RTN4 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the RTN4 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
RTN4 / Reticulon 4 |
| Short name: |
RTN4 Antibody / Reticulon 4 |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
reticulon 4 (Antibody to) / Reticulon 4 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
RTN4 and IDBG-52161 and ENSG00000115310 and 57142, RTN4 and IDBG-633945 and ENSBTAG00000011104 and 359718, Rtn4 and IDBG-157815 and ENSMUSG00000020458 and 68585, nuclei, poly(A) RNA binding, this GO :0001525 and angiogenesis and biological process this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005635 and nuclear envelope and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006915 and apoptotic process and biological process this GO :0007399 and nervous system development and biological process this GO :0007413 and axonal fasciculation and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0021801 and cerebral cortex radial glia guided migration and biological process this GO :0030176 and integral component of endoplasmic reticulum membrane and cellular component this GO :0030308 and negative regulation of cell growth and biological process this GO :0030334 and regulation of cell migration and biological process this GO :0030517 and negative regulation of axon extension and biological process this GO :0042981 and regulation of apoptotic process and biological process this GO :0042995 and cell projection and cellular component this GO :0043025 and neuronal cell body and cellular component this GO :0044822 and poly(A) RNA binding and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0050770 and regulation of axonogenesis and biological process this GO :0050771 and negative regulation of axonogenesis and biological process this GO :0051960 and regulation of nervous system development and biological process this GO :0060317 and cardiac epithelial to mesenchymal transition and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0071786 and endoplasmic reticulum tubular network organization and biological process this GO :2000172 and regulation of branching morphogenesis of a nerve and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0044822 : poly(A) RNA binding, this GO :0044822 : poly(A) RNA binding, reticulon 4 |
| Identity: |
14085 |
| Gene: |
RTN4 |
More about : RTN4 |
| Long gene name: |
reticulon 4 |
| Synonyms: |
NSP-CL KIAA0886 NOGO ASY |
| Locus: |
2p16, 1 |
| Discovery year: |
2000-11-28 |
| GenBank acession: |
AF087901 |
| Entrez gene record: |
57142 |
| Pubmed identfication: |
10667797 10773680 |
| Havana BLAST/BLAT: |
OTTHUMG00000129337 |