| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
TIGIT |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
Western blot: 1:2000 |
| Notes: |
Titration of the TIGIT antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This TIGIT antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q495A1 |
| Purity: |
Antigen affinity |
| Description: |
TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells |
| Immunogen: |
A portion of amino acids 12-142 from the human protein was used as the immunogen for this TIGIT antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the TIGIT antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
TIGIT |
| Short name: |
TIGIT Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
T cellular immunoreceptor including Ig and ITIM domains (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Cell surfaces, TIGIT and IDBG-50851 and ENSG00000181847 and 201633, TIGIT and IDBG-632631 and ENSBTAG00000011921 and 100140801, Tigit and IDBG-161101 and ENSMUSG00000071552 and 100043314, protein binding, this GO :0005102 and receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0032695 and negative regulation of interleukin-12 production and biological process this GO :0032733 and positive regulation of interleukin-10 production and biological process this GO :0050868 and negative regulation of T cell activation and biological process, this GO :0005102 : receptor binding, this GO :0005102 : receptor binding and also this GO :0005515 : protein binding, this GO :0005515 : protein binding, T cell immunoreceptor with Ig and ITIM domains |
| Identity: |
26838 |
| Gene: |
TIGIT |
More about : TIGIT |
| Long gene name: |
T-cell immunoreceptor with Ig and ITIM domains |
| Synonyms gene: |
VSIG9 VSTM3 |
| Synonyms gene name: |
V-set and immunoglobulin domain containing 9 V-set and transmembrane domain containing 3 T cell immunoreceptor with Ig and ITIM domains |
| Synonyms: |
FLJ39873 DKFZp667A205 |
| Locus: |
3q13, 31 |
| Discovery year: |
2006-02-07 |
| GenBank acession: |
AK097192 |
| Entrez gene record: |
201633 |
| Pubmed identfication: |
19011627 |
| RefSeq identity: |
NM_173799 |
| Classification: |
V-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000159331 |