| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
DRP1 (DNM1L) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the DRP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This DRP1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O00429 |
| Purity: |
Antigen affinity |
| Description: |
Mediates membrane fission through oligomerization into membrane- associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism, Required for normal brain development, Through its function in mitochondrial division, [UniProt], by suppressing oxidative damage, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, including that of cerebellum, Functions in mitochondrial and peroxisomal division |
| Immunogen: |
This DRP1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 557-590 amino acids from the C-terminal region of human DRP1/DNM1L |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the DRP1 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
DRP1 (DNM1L) |
| Short name: |
DRP1 Antibody (DNM1L) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
DRP1 (Antibody to) (dynamin 1-like) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Cell surfaces, DLP1 and DRP1 and DVLP and DYMPLE and EMPF and HDYNIV, DNM1L and IDBG-26348 and ENSG00000087470 and 10059, DNM1L and IDBG-638362 and ENSBTAG00000011395 and 540892, Dnm1l and IDBG-136828 and ENSMUSG00000022789 and 74006, protein homodimerization activity, this GO :0000266 and mitochondrial fission and biological process this GO :0001836 and release of cytochrome c from mitochondria and biological process this GO :0003374 and dynamin polymerization involved in mitochondrial fission and biological process this GO :0003924 and GTPase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005525 and GTP binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005777 and peroxisome and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005829 and cytosol and cellular component this GO :0005874 and microtubule and cellular component this GO :0005905 and coated pit and cellular component this GO :0006184 and GTP catabolic process and biological process this GO :0006897 and endocytosis and biological process this GO :0006915 and apoptotic process and biological process this GO :0006921 and cellular component disassembly involved in execution phase of apoptosis and biological process this GO :0008289 and lipid binding and molecular function this GO :0010821 and regulation of mitochondrion organization and biological process this GO :0016020 and membrane and cellular component this GO :0016559 and peroxisome fission and biological process this GO :0030054 and cell junction and cellular component this GO :0030672 and synaptic vesicle membrane and cellular component this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0032459 and regulation of protein oli this GO merization and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0043234 and protein complex and cellular component this GO :0043653 and mitochondrial fragmentation involved in apoptotic process and biological process this GO :0045087 and innate immune response and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0050714 and positive regulation of protein secretion and biological process this GO :0051289 and protein homotetramerization and biological process this GO :0061025 and membrane fusion and biological process this GO :0070266 and necroptotic process and biological process this GO :0070584 and mitochondrion morphogenesis and biological process this GO :0070585 and protein localization to mitochondrion and biological process this GO :0090141 and positive regulation of mitochondrial fission and biological process this GO :0090149 and membrane fission involved in mitochondrial fission and biological process this GO :0090200 and positive regulation of release of cytochrome c from mitochondria and biological process this GO :1900063 and regulation of peroxisome organization and biological process this GO :2001244 and positive regulation of intrinsic apoptotic signaling pathway and biological process, this GO :0003924 : GTPase activity, this GO :0003924 : GTPase activity and also this GO :0005515 : protein binding and also this GO :0005525 : GTP binding and also this GO :0008289 : lipid binding and also this GO :0031625 : ubiquitin protein ligase binding and also this GO :0042802 : identical protein binding and also this GO :0042803 : protein homodimerization activity, this GO :0005515 : protein binding, this GO :0005525 : GTP binding, this GO :0008289 : lipid binding, this GO :0031625 : ubiquitin protein ligase binding, this GO :0042802 : identical protein binding, this GO :0042803 : protein homodimerization activity, dynamin 1-like |
| Identity: |
2973 |
| Gene: |
DNM1L |
More about : DNM1L |
| Long gene name: |
dynamin 1 like |
| Synonyms: |
DRP1 DVLP HDYNIV DYMPLE VPS1 |
| Locus: |
12p11, 21 |
| Discovery year: |
2000-04-12 |
| GenBank acession: |
AF000430 |
| Entrez gene record: |
10059 |
| Pubmed identfication: |
9348079 9731200 |
| RefSeq identity: |
NM_012062 |
| Havana BLAST/BLAT: |
OTTHUMG00000169451 |